An illustration of a lymphoid nodule (follicle) from a mouse spleen showing a well developed germinal center (GC). The germinal center is surrounded by its mantle (cortex) of hematoxilyn stained (light blue) lymphocytes. In the germinal center the Follicular Dendritic Cell (FDC) network is visualized histochemically using the monoclonal antibody, FDC-M1, in conjunction with biotin amplification and aminoethyl carbazole development. Note the crescent shaped magenta-colored FDC Network.