Electron micrograph showing iccosome dispersion and endocytosis of iccosomes by germinal center B lymphocytes (See REF button). The iccosomes are outlined by the black stained immune complexes. The black represents the reaction product formed at the site of the enzyme, horse radish peroxidase (or HRP), used as the antigen. The two iccosomes associated with the large B cell, which are indicated by two opposing arrows, are shown enlarged in the inset located in the left bottom corner. Theseiccosomes are surrounded by sheet-like veils for endocytosis. Most of the iccosomes are dispersed among the B cells of the forming germinal center. The upper left inset shows enlarged a group of iccosomes located intercellularly as indicated by the arrow heads. Iccosome dispersion and endocytosis take place typically around Day 3 after antigenic challenge. The result of the endocytosis of the iccosomal antigen is seen at the white arrow. For further details the reader is referred to the original publication (see REF button below).