Interphase FISH Examples



13 and 21 Probes          18, X, and Y Probes

This is an example of the Aneuploid Screen test where interphase nuclei from amniotic fluid cells have been combined with DNA probes for chromosomes 13, 18, 21, X, and Y. The nucleus on the left has been hybridized to probes for chromosomes 13 (green), and 21 (red). The nucleus on the right has been hybridized to probes for chromosomes 18 (aqua), X (green), and Y (red). Since there are two signals each for chromosomes 13, 18, and 21 and one signal each for the X and Y chromosome this fetus is a normal male with respect to the Aneuploid Screen test.



13 and 21 Probes          18 and X Probes

This Aneuploid Screen test shows a female fetus with trisomy-21. The nucleus on the left has been hybridized to probes for chromosomes 13 (green), and 21 (red) and clearly has three red signals. The nucleus on the right has been hybridized to probes for chromosomes 18 (aqua), X (green), and Y (red). Since it has two green signals and no red signal it is female.



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