Newborn female, dysmorphic facial features





CT noncontrast




CT coronal reconstructions                                                                                    CT 3D  reconstructions (anterior view)




Findings:

Diffuse thinning of cortical mantle with absence of septum. Fused thalami and orbits.

DDX:

For cortical thinning:  Severe hydrocephalus, hydranencephaly, holoprosencephaly.



Diagnosis:

Alobar holoprosencephaly.


Discussion:

Absence of septum help distinguish holoprosencephaly from the other DDx.



Submitted by Paritosh Khanna, MD, UW Neuroradiology Fellow

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