Publications

  1. Jan S. Krouwer: Approaches To the Synthesis of Benzene Bisepoxides, Ph.D. Thesis, M.I.T., Cambridge, MA, 1973.
  2. Jan S. Krouwer and Bernard M. Babior: The Mechanism of Action of Ethanolamine Ammonia-Lyase. Studies with Formylmethylcobalamin, Fed. Proc., 35, 1541 (1976), (Abstract).
  3. Jan S. Krouwer and Bernard M. Babior: The Mechanism of Action of Ethanolamine Ammonia-Lyase. Reaction of a Postulated Organocorrin Intermediate with Enzyme, J. Biol. Chem., 252, 5004-5009 (1977).
  4. Jan S. Krouwer and Bernard M. Babior: The Mechanism of Cobalamin-Dependent Rearrangements, Molecular and Cellular Biochemistry, 15, 89-108 (1977).
  5. Jan S. Krouwer, Richard M. Schultz, and Bernard M. Babior: Aminoacetaldehyde, a Substrate Analog for Ethanolamine Ammonia-Lyase, a B12-dependent Enzyme, J. Biol. Chem., 253, 1041-1047 (1978).
  6. Jan S. Krouwer and Joe P. Richmond: The Synthesis and Reactions of Enamine N-oxides, J. Org. Chem., 43, 2464-2466 (1978).
  7. Bernard M. Babior and Jan S. Krouwer: The Mechanism of Action of B12-dependent Enzymes, Critical Reviews in Biochemistry, 6, 35-102 (1979).
  8. Jan S. Krouwer, Barton Holmquist, Ruby S. Kipnes, and Bernard M. Babior: The Mechanism of Action of Ethanolamine Ammonia-Lyase, an Adenosylcobalamin-dependent Enzyme. Evidence that Carbon-Cobalt Bond Cleavage is Driven in Part by Conformational Alternations of the Corrin Ring, Biochim. Biophys Acta, 612, 153-159 (1980).
  9. Jan S. Krouwer and Luis P. Leon: Routine Assay for Serum Thyroxine Using the Technicon SMAC Biochemical Analyzer, Clin. Chem., 26, 1067 (1980), (Abstract).
  10. Steven W. Graves, Jan S. Krouwer, and Bernard M. Babior: The Mechanism of Ethanolamine Ammonia-Lyase, an AdoCbl-dependent Enzyme. Studies with Isopropanolamine, A Substrate for the Enzyme. J. Biol. Chem., 255, 7444-7448 (1980).
  11. Jan S. Krouwer: Observations on Comparisons of Within-Run and Day-to-Day Precision, Clin. Chem., 27, 202 (1981), (Letter). Clin. Chem., 27, 629, (1981) Publisher correction.
  12. Jan S. Krouwer and Brian Schlain: A Statistical Method for Estimation of a Random Interference Component in Method Comparison Studies, Clin. Chem., 27, 1061 (1981), (Abstract).
  13. Douglas K. Chu, Jan S. Krouwer, Mary Ellen McDermott, Neil M. Wolfman, and Shyun L. Yun: An Investigation of the Stability of the IFCC AST and ALT Reagents, Clin. Chem., 28, 1599 (1982), (Abstract).
  14. Chien-Kuo Yeh, Jan S. Krouwer, and Roger Bauer: An Improved Uric Acid Method for Technicon SMAC System, Clin. Chem., 29 1285 (1983), (Abstract).
  15. Jan S. Krouwer and Robin Rabinowitz: How to Improve Estimates of Imprecision, Clin. Chem., 30, 290-292 (1984).
  16. Jan S. Krouwer and Michael Lynch: Transaminase Assay Using Pyridoxal Phosphate Coenzyme with Addition of Amino Polymer to Remove Unbound Coenzyme. Patent Application #3920038.
  17. Jan. S. Krouwer, Patricia E. Garrett, and Sanford R. Kurtz: A Method to Optimize Calibration Frequency, Clin. Chem., 31, 1017 (1985) (Abstract).
  18. Patricia E. Garrett and Jan S. Krouwer: Method Evaluation II: Precision and Sensitivity Considerations: J. of Clinical Immunoassay, 8, 165-168 (1985).
  19. Jan. S. Krouwer: Errors in Calculating Minimum Detectable Dose, Clin. Chem., 32, 1187 (1986) (Abstract).
  20. Jan S. Krouwer: Improving the Reporting of Immunoassay Specificity, Clin. Chem., 32, 1980 (1986).
  21. Jan S. Krouwer and William N. Stewart: Correction of Precision Equations in NCCLS EP5-T, (Letter) Clin. Chem., 33, 1104 (1987).
  22. Jan S. Krouwer: A Strategy For Dealing With Values Close to The Medical Decision Point (Abstract) Clin. Chem., 33, 910 (1987).
  23. Jan S. Krouwer: Cumulative Distribution Analysis Graphs - An Alternative to ROC Curves, Clin. Chem., 33, 2305-6 (1987).
  24. Jan S. Krouwer: A Multi-factor Design for the Evaluation of Random Access Analyzers, (Abstract) Clin. Chem., 34, 1192-3 (1988).
  25. Jan S. Krouwer and Jean O'Malley: Evaluation Of an Ionized Calcium/pH Analyzer, (Abstract) Clin. Chem., 34, 1234 (1988).
  26. Jan S. Krouwer, William N. Stewart, and Brian Schlain: A Multi-factor Design for the Evaluation of Random Access Analyzers, Clin. Chem., 34, 1894-6 (1988).
  27. Jan S. Krouwer: Book Review of Multivariate Interpretation of Clinical Laboratory Data, Clin. Chem., 34, 2187 (1988).
  28. Lisa E. Crosby and Jan S. Krouwer: Diagnostic Efficacy of Magic Lite PTH, (Abstract) Clin. Chem., 35, 1187-88 (1989).
  29. Jan S. Krouwer: The CV at The Detection Limit, (Letter) Clin. Chem., 35, 901 (1989).
  30. Brian Schlain and Jan S. Krouwer: Multi-factor Designs II. A Design for Identifying Instruments with Sample-to-sample Carryover and Drift. Clin. Chem., 35, 2118-2120 (1989)
  31. Brian Schlain and Jan S. Krouwer: Multi-Factor Designs III. A Multi-factor Design With Unequal Spacing of Concentration Levels, (Abstract) Clin. Chem., 36, 1177 (1990).
  32. Jan S. Krouwer: Multi-Factor Designs IV. How Multi-factor Designs Improve the Estimate of Total Error by Accounting for Protocol Specific Bias. Chem. Chem., 37, 26-29 (1991).
  33. Jan S. Krouwer: Estimating Total Analytical Error and Its Sources: Techniques to Improve Method Evaluation. Arch Pathol Lab Med., 116, 726-731 (1992).
  34. H.M.J. Goldschmidt and Jan S. Krouwer: Multi-factor Experimental Designs for Evaluations, in "Evaluation Methods in Laboratory Medicine," R. Haeckel, Ed., VCH, Weinheim, 1993.
  35. Jan S. Krouwer and Brian Schlain: A Method to Quantify Deviations From Nonlinearity. Clin. Chem., 39, 1227-8 (1993) (Abstract).
  36. Jan S. Krouwer and Brian Schlain: A Method to Quantify Deviations From Nonlinearity. Clin. Chem., 39, 1689-93, (1993).
  37. Jan S. Krouwer: Book Review of Medical Uses of Statistics, Second Edition Clin. Chem., 39, 2214-5, (1993).
  38. Carl C. Garber, Larry W. Clark, Patricia E. Garrett, David J. Hassemer, Mary Lou Kotschi, Jan S. Krouwer, Richard B. Passey, Donald M. Powers: Preliminary Evaluation of Quantitative Clinical Chemistry Laboratory Methods - Second Edition; Tentative Guideline NCCLS EP10 T2, September, 1993, NCCLS, 771 E. Lancaster Ave. Villanova, PA.
  39. Jan S. Krouwer: A Modification of EP10 to Include Interference Screening. Clin. Chem. 40, 1118-9 (1994) (Abstract).
  40. Jan S. Krouwer: Book Review of Statistical Methods in Analytical Chemistry, Clin. Chem. 40, 955 (1994).
  41. Brian Schlain and Jan S. Krouwer: Reply to Letter to Editor about: A Method to Quantify Deviations From Nonlinearity. Clin. Chem., 39, 1689-93, (1993), Clin. Chem., 40, 1785-6 (1994).
  42. Jan S. Krouwer and Katherine L. Monti: A Modification of EP10 to Include Interference Screening,. Clin. Chem., 41, 325-6 (1995).
  43. Jan S. Krouwer and Katherine L Monti: A Simple Graphical Method to Evaluate Laboratory Assays, Eur. J. Clin. Chem. and Clin. Biochem., 33, 525-527 (1995).
  44. Jan S. Krouwer: Use of analytical goals by health care manufacturers, in Frontiers in Laboratory Practice Research. in Proceeding of 1995 Institute on Critical Issues in Health Laboratory Practice: Frontiers in Laboratory Practice Research US Dept. of Health and Human Services 1996.
  45. Jan S. Krouwer: Using capability indices to evaluate clinical laboratory assays, Clin. Chem. 34 S134 (1996) (Abstract).
  46. Donna S. Orvedahl, Andy Chan, Susan Degnan, Christopher Murphy, Sheryl Fennel, and Jan S. Krouwer: New generation of solid state sensors for electrochemical measurements. Clin. Chem. 34 S281 (1996) (Abstract).
  47. Eduard K.A. Winckers and Jan S. Krouwer: First clinical evaluation of the lactate sensor of the CCD 860. Clin. Chem. 34 S278-79 (1996) (Abstract).
  48. Jan S. Krouwer: Preliminary Evaluation of Quantitative Clinical Chemistry Laboratory Methods; Approved Guideline NCCLS EP10 A, NCCLS, 771 E. Lancaster Ave. Villanova, PA., 1998.
  49. Jan S. Krouwer: Beware the Percent Completion Metric. Research Technology Management, 41, 13-15, (1998).
  50. Jan S. Krouwer: Development of NCCLS consensus based EP10 software. Clin. Chem. 44, A61-62. (Abstract).
  51. Jan S. Krouwer: Product Development for the Clinical Laboratory. in "Encyclopedia of Analytical Chemistry: Instrumentation and Applications", Robert A. Meyers, Ed., J. Wiley,  Oct. 2000.
  52. Jan S. Krouwer, et. al., A Framework for NCCLS Evaluation Protocols; Proposed Guideline NCCLS EP19P, July, 2000, NCCLS, 771 E. Lancaster Ave. Villanova, PA., 1998.
  53. John Benco, Jan S. Krouwer: Method of Measuring pH, US Patent 60/115,039 Filed Jan. 7, 1999.
  54. Evaluation of Assay Systems html pdf Clin. Chem. News, 27, 10-14, 2001
  55. Jan S. Krouwer: How to Improve Total Error Modeling by Accounting for Error Sources Beyond Imprecision and Bias, Clin. Chem., 47, 1329-30 2001 (Letter).
  56. Daniel W. Tholen, Martin Kroll, Jan S. Krouwer, et. al. Evaluation of the linearity of quantitative analytical methods; Proposed Guideline - Second Edition NCCLS EP6P2, NCCLS, 771 E. Lancaster Ave. Villanova, PA., 2001.
  57. Jan S. Krouwer, J. Rex Astles, W. Gregory Cooper, et. al., Estimation of Total Analytical Error for Clinical Laboratory Methods; Proposed Guideline NCCLS EP21P, NCCLS, 771 E. Lancaster Ave. Villanova, PA., 2002.
  58. Jan S. Krouwer, Setting Performance Goals and Evaluating Total Analytical Error for Diagnostic Assays Clin. Chem. 48, 919-927 2002
  59. Jan S. Krouwer, Assay Development and Evaluation, a Manufacturer's Perspective, AACC Press, Washinton, DC, 2002
  60. Jan S. Krouwer, Using a Learning Curve Approach to Reduce Laboratory Error, Accred. Qual. Assur., 7 461-467 2002.
  61. Jan S. Krouwer, Proposal to add an optional Recommendations section to Clinical Chemistry Abstracts, Clin. Chem. 48 2294 2002. (Letter).
  62. Jan S. Krouwer, A Critique of the GUM Method of Estimating and Reporting Uncertainty in Diagnostic Assays, Clin. Chem. 49:1218-1221 2003.
  63. Jan S. Krouwer, Problems with the NCEP (National Cholesterol Education Program) Recommendations for Cholesterol Analytical Performance. Arch Pathol Lab Med 127, 1249 (2003). (Letter).
  64. Jan S. Krouwer,ISO 9001 has had no effect on quality in the in-vitro medical diagnostics industry. Accred. Qual. Assur., 9: 39-43 (2004).
  65. Jan S. Krouwer, An improved FMEA (Failure Mode Effects Analysis) for Hospitals. Arch Pathol Lab Med 2004;128:663-667
  66. Jan S. Krouwer, Problems with the NCEP (National Cholesterol Education Program) There is nothing wrong with the concept of a root cause. Int J Qual Health Care 2004 16: 263. (Letter).
  67. Managing Risk in Hospitals using Integrated Fault Trees and Failure Mode Effects and Criticality Analysis. Jan S. Krouwer, AACC Press, Washington DC, 2004
  68. Jan S. Krouwer: Adding fault trees to FMEAs to reduce risk in assay error. Clin. Chem. 50, A38. (2004) (Abstract).

Software (distributed on request with publications)

  1. Paper 26: Turbo Basic DOS program.
  2. Paper 42: Visual Basic Windows program.
  3. Paper 43: Visual Basic Windows program.
  4. Paper 48: Visual Basic for Applications (Excel) program.
  5. Paper 57: Visual Basic for Applications (Excel) program.
  6. Paper 65: Visual Basic.Net program.

Presentations

  1. Jan S. Krouwer and Patricia E. Garrett: Evaluating Immunoassays: Where to Start and How to Finish with Confidence in Your Choice. Clinical Ligand Assay Society National Meeting May 1988 Washington, DC.
  2. Jan S. Krouwer and Patricia E. Garrett: Evaluating Immunoassays: Where to Start and How to Finish with Confidence in Your Choice. Clinical Ligand Assay Society National Meeting May 1989 Los Angeles, CA.
  3. Daniel W. Chan, Patricia E. Garrett, Jan S. Krouwer, and Marie Perlstein: Practical Immunoassay. AACC National Meeting, July 1989 New Orleans, LA.
  4. Jan S. Krouwer and Patricia E. Garrett: Evaluating Immunoassays: Where to Start and How to Finish with Confidence in Your Choice. Clinical Ligand Assay Society National Meeting May 1990 Philadelphia, PA.
  5. Jan S. Krouwer: Issues in Immunoassay Evaluation. NECLAS Meeting, January 1991 Boston, MA.
  6. Jan S. Krouwer and Patricia E. Garrett: Evaluating Immunoassays: Where to Start and How to Finish with Confidence in Your Choice. Clinical Ligand Assay Society National Meeting May 1991 Chicago, IL.
  7. Jan S. Krouwer: Total Error and Taguchi: Techniques to Improve Method Evaluation. XXI CAP Conference on Validation of Clinical Laboratory Methods and Instrumentation. October 1991, San Diego, CA.
  8. Jan S. Krouwer: Use of analytical goals by health care manufacturers. Frontiers in Laboratory Practice Research. October 1995, Atlanta, GA.
  9. Jan S. Krouwer Graphical Methods to Evaluate Laboratory Assays, Seminar Kwaliteitscontrole, February, 1996 Zeist, Holland - see: Sjaak Ekema, Praktische toepassing dagelijkse kwaliteitscontrole. Een seminar met J. O. Wetsgard and J. S. Krouwer Analyse, 1996; 163-165 (in Dutch).
  10. Jan S. Krouwer and Keith McLain: Predicting and Improving Product Quality, Critical Care Business Leadership Forum, Coalition for Critical Care, September, 1998 Andover, MA.
  11. Jan S. Krouwer: Using Reliability Growth Management to Shorten Product Development Time, Society of Concurrent Engineering, September, 1998 Waltham, MA.
  12. Jan S. Krouwer: Graphical Evaluation of Immunoassays, CLAS, May, 1999, Philadelphia, PA.
  13. Jan S. Krouwer: Using a Learning Curve Approach to Reduce Laboratory Errors. Quality in the Spotlight, October, 2001 Antwerp, Belgium.
  14. Jan S. Krouwer: Improving Method Evaluations. NERCE, April, 2003, Boxborough, MA.
  15. Jan S. Krouwer: Reliability growth management in the medical diagnostics industry. IEEE, January, 2004, Chelmsford, MA.