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Asexual Reproduction

Asexual reproduction is the formation of new individuals from the cell(s) of a single parent.

It is very common in plants; less so in animals.

Asexual Reproduction in Plants

All plant organs have been used for asexual reproduction, but stems are the most common.

Stems

In some species, stems arch over and take root at their tips, forming new plants.

The horizontal above-ground stems (called stolons) of the strawberry (shown here) produce new daughter plants at alternate nodes.

Underground stems [View] are used for asexual reproduction as well as for food storage.

Irises and day lilies, for example, spread rapidly by the growth of their rhizomes.

Leaves

This photo shows the leaves of the common ornamental plant Bryophyllum (also called Kalanchoë) . Mitosis at meristems along the leaf margins produce tiny plantlets that fall off and can take up an independent existence.

Roots

Some plants use their roots for asexual reproduction. The dandelion is a common example. Trees, such as the poplar or aspen, send up new stems from their roots. In time, an entire grove of trees may form — all part of a clone of the original tree.

Plant Propagation

Commercially-important plants are often deliberately propagated by asexual means in order to keep particularly desirable traits (e.g., flower color, flavor, resistance to disease).

Cuttings may be taken from the parent and rooted [More].

Grafting is widely used to propagate a desired variety of shrub or tree. All apple varieties, for example, are propagated this way.

Apple seeds are planted only for the root and stem system that grows from them. After a year's growth, most of the stem is removed and a twig (scion) taken from a mature plant of the desired variety is inserted in a notch in the cut stump (the stock). So long the cambiums of scion and stock are united and precautions are taken to prevent infection and drying out, the scion will grow. It will get all its water and minerals from the root system of the stock. However, the fruit that it will eventually produce with be identical (assuming that it is raised under similar environmental conditions) to the fruit of the tree from which the scion was taken.

Apomixis

Citrus trees and many other species of angiosperms use their seeds as a method of asexual reproduction; a process called apomixis. Hybridization between different species often yields infertile offspring. [Link to a discussion of this postzygotic isolating mechanism.] But in plants, this does not necessarily doom the offspring. Many such hybrids use apomixis to propagate themselves.

The many races of Kentucky bluegrass growing in lawns across North America and the many races of blackberries are two examples of sterile hybrids that propagate successfully by apomixis.

Recently, an example of apomixis in gymnosperms was discovered (see Pichot, C., et al, in the 5 July 2001 issue of Nature). In a rare cypress, the pollen grains are diploid, not haploid, and can develop into an embryo when they land on either

Is this paternal apomixis in a surrogate mother a desperate attempt to avoid extinction?

Breeding apomictic crop plants

Many valuable crop plants (e.g., corn) cannot be propagated by asexual methods like grafting.

Agricultural scientists would dearly love to convert these plants to apomixis: making embryos that are genetic clones of themselves rather than the product of sexual reproduction with its inevitable gene reshuffling. After 20 years of work, an apomictic corn (maize) has been produced, but it does not yet produce enough viable kernels to be useful commercially.

Asexual Reproduction in Animals

Budding

Here, offspring develop as a growth on the body of the parent.

In some species, e.g., jellyfishes and many echinoderms, the buds break away and take up an independent existence.

In others, e.g., corals, the buds remain attached to the parent and the process results in colonies of animals.

Budding is also common among parasitic animals, e.g., tapeworms.
Link to two examples.

Fragmentation

As certain tiny worms grow to full size, they spontaneously break up into 8 or 9 pieces. Each of these fragments develops into a mature worm, and the process is repeated.

Parthenogenesis

In parthenogenesis ("virgin birth"), the females produce eggs, but these develop into young without ever being fertilized.

Parthenogenesis occurs in some fishes, several kinds of insects, and a few species of frogs and lizards. It does not normally occur in mammals because of their imprinted genes. However, using special manipulations to circumvent imprinting, laboratory mice have been produced by parthenogenesis. [Link]

In a few nonmammalian species it is the only method of reproduction, but more commonly animals turn to parthenogenesis only under certain circumstances. Examples:

Parthenogenesis is forced on some species of wasps when they become infected with bacteria (in the genus Wolbachia). Wolbachia can pass to a new generation through eggs, but not through sperm, so it is advantageous to the bacterium for females to be made rather that males.

In these wasps (as in honeybees), However, in Wolbachia-infected females, all their eggs undergo endoreplication producing diploid eggs that develop into females without fertilization; that is, by parthenogenesis.

Treating the wasps with an antibiotic kills off the bacteria and "cures" the parthenogenesis!

Apis mellifera capensis

Occasionally worker honeybees develop ovaries and lay unfertilized eggs. Usually these are haploid, as you would expect, and develop into males. However, workers of the subspecies Apis mellifera capensis (the Cape honeybee) can lay unfertilized diploid eggs that develop into females (who continue the practice). The eggs are produced by meiosis, but then the polar body nucleus fuses with the egg nucleus restoring diploidy (2n). (The phenomenon is called automictic thelytoky.)

Why Choose Asexual Reproduction?

Perhaps the better question is: Why not?

After all, asexual reproduction would seem a more efficient way to reproduce. Sexual reproduction requires males but they themselves do not produce offspring.

Two general explanations for the overwhelming prevalence of sexually-reproducing species over asexual ones are:

Purging Harmful Mutations

Most mutations are harmful — changing a functional allele to a less or nonfunctional one.

An asexual population tends to be genetically static. Mutant alleles appear but remain forever associated with the particular alleles present in the rest of that genome. Even a beneficial mutation will be doomed to extinction if trapped along with genes that reduce the fitness of that population.

But with the genetic recombination provided by sex, new alleles can be shuffled into different combinations with all the other alleles available to the genome of that species. A beneficial mutation that first appears alongside harmful alleles can, with recombination, soon find itself in more fit genomes that will enable it to spread through a sexual population.

Evidence (from Paland and Lynch in the 17 February 2006 issue of Science):

Some strains of the water flea Daphnia pulex (a tiny crustacean) reproduce sexually, others asexually. The asexual strains accumulate deleterious mutations in their mitochondrial genes four times as fast as the sexual strains.

Evidence (from Goddard et al. in the 31 March 2005 issue of Nature):

Budding yeast missing two genes essential for meiosis adapt less rapidly to growth under harsh conditions than an otherwise identical strain that can undergo genetic recombination. Under good conditions, both strains grow equally well.

Evidence (from Rice and Chippindale in the 19 October 2001 issue of Science):

Using experimental Drosophila populations, they found that a beneficial mutation introduced into chromosomes that can recombine did — over time — increase in frequency more rapidly than the same mutation introduced into chromosomes that could not recombine.

So sex provides a mechanism for testing new combinations of alleles for their possible usefulness to the phenotype:

Some organisms may still gain the benefits of genetic recombination while avoiding sex. Many mycorrhizal fungi use asexual reproduction only. However, at least two species have been shown to have multiple — similar — copies of the same gene; that is, are polyploid. Perhaps recombination between these (during mitosis?) enables these organisms to avoid the hazards of accumulating deleterious mutations. (See the paper by Pawlowska and Taylor in the 19 Feb 2004 issue of Nature.)

But there are many examples of populations that thrive without sex, at least while they live in a stable environment.

Rapid Adaptation to a Changing Environment

As we have seen (above), populations without sex are genetically static. They may be well-adapted to a given environment, but will be handicapped in evolving in response to changes in the environment. One of the most potent environmental forces acting on a species environment is its parasites.

The speed with which parasites like bacteria and viruses can change their virulence may provide the strongest need for their hosts to have the ability to make new gene combinations. So sex may be virtually universal because of the never-ending need to keep up with changes in parasites.

Evidence:

The idea that a constantly-changing environment, especially with respect to parasites, drives evolution is often called the Red Queen hypothesis. It comes from Lewis Carroll's book Through the Looking Glass, where the Red Queen says "Now here, you see, it takes all the running you can do to keep in the same place".

Probably Both

The possibilities outlined above are not mutually exclusive and a recent study [see Morran, L. T., et al., in Nature, 462:350, 19 November 2009] suggests that both forces are at work in favoring sexual reproduction over its alternatives.

The organism for testing these theories was Caenorhabditis elegans. While C. elegans does not reproduce asexually, most worms are hermaphrodites and usually reproduce by self-fertilization with each individual fertilizing its own eggs. This quickly results in its genes becoming homozygous and thus fully-exposed to natural selection just as they are in asexually-reproducing species.

Hermaphrodites have two X chromosomes and self-fertilization ("selfing") usually produces more of the same; that is, hermaphrodites produce more hermaphrodites. However, an occasional nondisjunction generates an embryo with a single X chromosome and this develops into a male. These males can mate with hermaphrodites (their sperm is preferred over the hermaphrodites own) and, in fact, such "outcrossing" produces a larger number of offspring. It also produces 50% hermaphrodites and 50% males.

Testing the role of outcrossing vs. self-fertilization in maintaining fitness in the face of an increased mutation rate.

These workers developed six strains of worms:

All the strains were exposed to a chemical mutagen that increased the spontaneous mutation rate some fourfold.

The results: After 50 generations, the

Fitness was measured by placing the worms in a petri dish with a barrier that they had to cross to reach their food (E. coli).

The conclusion: the genetic recombination provided by outcrossing protected the worms from loss of fitness even in the face of an increase in mutation rate.

Testing the role of outcrossing vs. self-fertilization in the speed of adaptation to a changed environment.

For these tests, one of each category of mating types was exposed over 40 generations to a pathogenic bacterium (Serratia marcescens) that killed most worms when eaten by them.

The results: After 40 generations,

Since these studies were reported, the same team has expanded their experiments to examine the effects of evolution in the pathogen (Serratia marcescens), that is, to look for evidence of coevolution of host and parasite. (Reported by Morran, L. T., et al., in Science, 333: 216, 8 July 2011.)

Over 30 generations of worms, they harvested and tested the bacteria recovered from the bodies of worms that had died within 24 hours of infection. They found that:

Reproduction in Rotifers

Rotifers are microscopic invertebrates. They are assigned a phylum of their own (not discussed elsewhere in these pages). The phylum includes:

Laboratory studies show that monogonont rotifers favor asexual reproduction when they are living in a stable environment but shift to more sexual reproduction when placed in a varied or unfavorable environment. As they adapt to the new environment, they gradually switch back to asexual reproduction.

But how have the bdelloid rotifers that never engage in sexual reproduction managed to survive? How have they avoided the demands of the Red Queen; that is, avoided extinction at the hands of parasites?

One study (Wilson, C. G. and Sherman, P. W., Science, 327:574, 29 January 2010) reveals a mechanism. These tiny animals can be completely desiccated (dried out) and remain in suspended animation for years. In the desiccated state, they can be blown vast distances (some species are worldwide in their distribution). Once deposited in a moist environment (a few drops of water are sufficient), they resume an active life. Wilson and Sherman have shown that the desiccation that is harmless to the rotifers is lethal to their fungal parasite. So once dried, they are not only cured of their parasite, but can then be blown to a spot where they can resume an active life with no parasites present.

Another way in which these rotifers can avoid the evolutionary dead-end expected of asexually-reproducing organisms has been revealed by DNA sequencing of their genome. It turns out that they can purge their genome of deleterious alleles by gene conversion (during mitosis).


But in any case — despite its disadvantages — sexual reproduction is here to stay
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16 April 2014