Curriculum Vitae for Jonathan E. Phillips

ADDRESS:
               117 Florence Ave.
               Westfield, NJ 07090

               Schering-Plough Research Institute
               Pulmonary Group M/S 1700
               2015 Galloping Hill Road
               Kenilworth, NJ 07033     
TELEPHONE:
               Home Phone: (908)-232-4923
               Work Phone: (908)-740-5532
               Fax       : (908)-740-7175 
               Email     : jonp291@comcast.net
D.O.B: 
               September 12, 1970

DEGREES & DIPLOMAS:

Doctor of Philosophy in Chemical Engineering, December 1999, University of Illinois at Chicago, Chicago, Illinois. Pulmonary Bio-Physics Laboratory. Thesis: Vectorial Ion and Water Transport across Respiratory Airway Epithelia.

Masters of Science in Chemical Engineering, December 1995, University of Illinois at Chicago, Chicago, Illinois. Thesis: Water Diffusion through an Entangled Polymer Gel (Mucus).

Bachelors of Science in Chemical Engineering, August 1993, Purdue University, West Lafayette, Indiana. Undergraduate Research Project: Diffusion along a Fractal Curve.

LICENSED PROFESSIONAL ENGINEER: New Jersey, No. GE44840

HONORS: Amoco Foundation Doctoral Fellowship, 1994-1996

Philip Hawley award for presentation at the Sigma Xi graduate student research forum March 26, 1998

Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award

First place for Graduate Student Presentation at American Institute of Chemical Engineers Poster Session April 14, 1999.

UIC Graduate College Travel Award, 1997-1999

Positions:

Associate Principle Scientist

Schering-Plough Research Institute

Kenilworth, New Jersey

Senior Scientist

Schering-Plough Research Institute

Kenilworth, New Jersey

Postdoctoral Fellow

Schering-Plough Research Institute

Kenilworth, New Jersey

Research Assistant in Department of Medicine

University of Illinois at Chicago

Chicago, Illinois

Teaching Assistant in Chemical Engineering Department

University of Illinois at Chicago

Chicago, Illinois

Machinist

Ophthalmology Machine Shop at UIC

Chicago, Illinois

Engineering Technician

UOP (Formerly Universal Oil Products)

Riverside, Illinois

Laboratory Technician

UOP

Riverside, Illinois

Owner

E and J Engraving

Crown Point, Indiana

Memberships in Professional Societies:

American Thoracic Society

American Institute of Chemical Engineers

Sigma Xi

Biophysical Society

American Physiological Society

Activities in Professional Organizations:

Pulmonary Research Group, Scientific Program Committee, 2002

Pulmonary Research Group, Board Member, 2003-present

Other Professional and Related Activities:

Co-Chairman, PRG Symposium , Glaxo-Smith-Kline, King of Prussia, PA, 9/03

Referee for The Journal of Applied Physiology

Research Advisior for the Following Students

Tarun Kukreja, Summer, 1995; The Relative Humidity above Saturated Salt Solutions. Illinois Mathematics and Science Academy

Katherine Moreno and Erica Wesley, Spring, 1996; The Measurement of the Viscosity of Liquids by Quasielastic Light Scattering. Illinois Mathematics and Science Academy

Lauren Miranda, Summer, 2003; Immunohistiology of Aquaporins in Ovine Airways. Rutgers University

Lunan Ji, Summer, 2006; 3-D CT Scan Reconstruction and Volume Measurement of Rat Nasal Sinuses. Columbia Universtiy

Presentations at Major Meetings

Presenter - Interactive Ion and Water Transport Across Airway Epithleia. 1996 Annual Meeting of the American Institute of Chemical Engineers, November 1996.

Presenter - Luminal to Basolateral Active Sodium and Water Transport Regulate Airway Hydration. 1998 Sigma Xi Graduate Student Research Forum, March 1998.

Presenter - Bidirectional Actively Coupled Water Transport Across Tracheal Epithelia. 1998 American Thoracic Society International Conference, April 1998.

Presenter - Intracellular Active Sodium and Coupled Water Transport Regulate Airway Hydration. 1998 Annual Meeting of the American Institute of Chemical Engineers, November 1998.

Invited Speaker - Water and Ion Transport Across Airway Epithelia, Respiratory and Critical Care Medicine Research Conference, Micheal Reese Hospital, December 1998.

Presenter - Pharmacological Augmentation of Airway Surface Hydration. Chicago Thoracic Society Annual Research Abstract Presentations, American Lung Association of Metropolitan Chicago, April 1999.

Presenter - Pharmacological Augmentation of Airway Surface Hydration. American Institute of Chemical Engineers Chicago Section Student Poster Session, Illinois Institute of Technology, April 1999.

Presenter - Vasopressin Increases Airway Transepithelial Water Fluxes. Experimental Biology '99, April 1999.

Presenter - Neuropeptide Y (NPY) Reduces Norepinephrine (NE) Induced Increases In Vectorial Water Fluxes Across Tracheal Epithelia. 1999 American Lung Association/American Thoracic Society International Conference, April 1999.

Invited Speaker - Mechanisms Regulating Airway Hydration, Respiratory and Critical Care Medicine Research Conference, UIC Hospital, October 1999.

Presenter - Amiloride Increases Methacholine Induced Tracheal Submucosal Gland Fluid Flux in Porcine Tracheal Epithelia. 2001 American Thoracic Society International Conference, May 2001.

Abstracts

Phillips, J., Wong, L., and Yeates, D.: Bidirectional Actively Coupled Water Transport Across Tracheal Epithelia. Am. J. Respir. Crit. Care Med. 157:A848, 1998.

Phillips, J. and Yeates, D.: Neuropeptide Y Reduces Norepinephrine Induced Increases in Vectorial Water Fluxes Across Tracheal Epithelia. Am. J. Respir. Crit. Care Med. 159:A294, 1999.

Phillips, J. and Yeates, D.: Vasopressin Increases Airway Transepithelial Water Fluxes. FASEB J. 13:A397, 1999.

Yeates, D., Phillips, J., Chen, B., and Wong, L.: Regulation of Transepithelial Water and Ion Transport: Control of the Mucociliary Transport System. J. Aerosol Med. 12:140, 1999.

Phillips, J., Hey, J., and Corboz, M.: Amiloride Increases Methacholine Induced Tracheal Submucosal Gland Fluid Flux in Porcine Tracheal Epithelia. Am. J. Respir. Crit. Care Med. 163:A406, 2001.

Phillips, J., Hey, J., and Corboz, M.: Effects of Neurokinin Agonists and Antagonists on Submucosal Gland Secretion from Porcine Ariways. Am. J. Respir. Crit. Care Med. 165:A722, 2002.

Varty, L., Phillips, J., Jia, Y., and Hey, J.: Differential a₂- and a₁-Adrenoceptor Realtime Vasomotor Contractions in Isolated Porcine Nasal Mucosa. Am. J. Respir. Crit. Care Med. 167:A425,2003.

Phillips, J., Hey, J., and Corboz, M.: Effects of Ion Transport Inhibitors on Methacholine Mediated Secretion from Porcine Airway Submucosal Glands. Am. J. Respir. Crit. Care Med. 167:A424 2003.

Phillips, J., Hseuh, D., Zhang, X., Spond, J., Sehring, S., Celly, C, Hey, J., Kreutner, W., and Minnicozzi, M.: Effects of Airway Irritants on Mucin Concentration in Rat Bronchoalveolar Lavage Fluid Measured by ELISA. Am. J. Respir. Crit. Care Med. 167:A426 2003.

Phillips, J. Case, N., Billah, M., Hey, J., and Minnicozzi, M.: Increased Work of Breathing in Allergic Guinea-Pig Model of Asthma is Attenuated by Betamethasone. FASEB J. 18:A1050, 2004.

Phillips, J., Case, N., Chapman, R., Hey, J., and Minnicozzi, M.: Activation of the IKCa1 Potassium Channel Elicits a Transient Hyperpolarization of Native Porcine Tracheal Epithelium. Pediatr. Pulmonol. Supplement 27:215-216.

Phillips, J., Case, N., Chapman, R., Hey, J., and Minnicozzi, M.: Pharmacological Characterization of Work of Breathing and Pulmonary Inflammation Reduction in an Allergic Guinea Pig Model of Asthma Proc. Am. Thorac. Soc. 2:A487 2005.

Phillips, J., Hey, J., and Chapman, R.: Time Course of Pulmonary Inflammation in a Cigarette Smoke-Induced Mouse Model of COPD. Proc. Am. Thorac. Soc. 3:A793 2006.

Chapman, R., House, A., Spond, J., Jones, H., Lamca, J., Celly, C., Prelusky, D., Ting, P., Chen, X., Phillips, J., Hey, J., Activity of an Inhaled PDE4 Inhibitor on Cellular Lung Inflammation and Lung Function in Allergen-Challenged Brown Norway Rats. Proc. Am. Thorac. Soc. 3:A340 2006.

Hipkin, R., Minnicozzi, M., Fan, X., Celly, C., Rindgen, D., Jakway, J., Kung, T., Billah, M., Egan, R., Narula, S., Hey, J., Lundell, D., Fine, J., Phillips, J., Chapman, R.: SCH 527123 is a Selective and Potent CXCR1/2 Antagonist Which Inhibits Neutrophil Recruitment and Mucus Production in Experimental Models of Obstructive Pulmonary Inflammation. Proc. Am. Thorac. Soc. 3:A582 2006.

Phillips, J., Ji, L., and Corboz, M.: Volume Quantification of Mouse, Rat, and Guinea Pig Paranasal Sinus Cavities by CT Imaging and Computer Assisted Three-Dimensional Reconstruction. Am. J. Respir. Crit. Care Med. 175:A671 2007.

Anthes, J., McLeod, R., Chapman, R., Jia, Y., and Phillips, J.: Changes in Upper and Lower Airway Inflammation Following Administration of Mometasone Furoate in Allergen-Challenged Brown Norway Rats. J. Allergy Clin. Immunol. 121:S205, 2008.

Smith, K., McClanahan, T., Smith, M., Levitan, D., Case, N., Natiello, M., Jones, H., Chapman, R.W., and Phillips, J..: Gene Expression Profiling in the Lungs of AKR/J Mice after Chronic Cigarette Smoke Exposure. Am. J. Respir. Crit. Care Med. 177:A228, 2008.

Phillips, J., Natiello, M., Fick, R., Chapman, R., and Smith, K.: Pulmonary Inflammation Inhibited by Isotype Control Antibodies in a Cigarette Smoke Induced AKR/J Mouse Model of COPD. Am. J. Respir. Crit. Care Med. 177:A608, 2008.

Phillips, J., Natiello, M., Kelly, G., House, A., Xie, L., Feng, K., Eckel, S., Anthes, J., and Chapman, R.: Allergic Rat Asthma Model to Assess the Therapeutic Index of Inhaled Corticosteroids. Am. J. Respir. Crit. Care Med. 177:A218, 2008.

Corboz, M., Rivelli, M., Skeans, S., McCormick, K., Chapman, R., Phillips, J., and Anthes, J.: Vasodilatory and Secretagogue Roles of the Prostaglandin D2 (PGD2) Receptor in Nasal Mucosa and Airways of Different Species. Am. J. Respir. Crit. Care Med. 179:A5699, 2009

Corboz, M., Rivelli, M., Desai-Merchant, A., Anand, M., Smith, K., Phillips, J., and Chapman, R.: Effects of Two Days Cigarette Smoke Exposure in Isolated Perfused Rat Lung and on Pulmonary Inflammation. Am. J. Respir. Crit. Care Med. 179:A2027, 2009

Phillips, J., Natiello, M., Kelly, G., House, A., Anthes, J., and Chapman, R.: Therapeutic Index of Inhaled Corticosteroids Assessed in an Allergic Rat Asthma Model Am. J. Respir. Crit. Care Med. 179:A5723, 2009.

Peer-Reviewed Publications

Phillips, J.E., L.B. Wong, and D.B. Yeates. 1999, Bidirectional Transepithelial Water Transport: Measurement and Governing Mechanisms. Biophys. J., 76(2):869-877.

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Phillips, J.E. and J.D. DeCicco. 1999, Choose the Right Mathematical Software. Chem. Eng. Progress, 95(7):69-74.

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Phillips, J.E. and D.B. Yeates. 2000, Bidirectional Transepithelial Water Transport: Chloride-Dependent Mechanisms J. Membrane Biol., 175(3):213-221.

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Fisher, K.V., A. Telser, J.E. Phillips, and D.B. Yeates. 2001, Regulation of Vocal Fold Transepithelial Water Fluxes. J. Appl. Physiol., 91:1401-1411.

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Phillips, J.E., J.A. Hey, and M.R. Corboz. 2002, Computer Assisted Measurement of Airway Gland Secretions by the Hillocks Technique. Comput. Methods Programs Biomed., 68:215-222.

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Phillips, J.E., J.A. Hey, and M.R. Corboz. 2002, Effects of Ion Transport Inhibitors on Methacholine-Mediated Secretion of Fluid from Porcine Airway Submucosal Glands. J. Appl. Physiol., 93:873-881.

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Phillips, J.E., J.A. Hey, and M.R. Corboz. 2003, Tachykinin NK₃ and NK₁ Receptor Activation Elicits Secretion from Porcine Airway Submucosal Glands. Br. J. Pharmacol., 138:254-260

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Phillips, J.E., N. Case, R.W. Chapman, J.A. Hey, and M. Minnicozzi. 2006, An Enzyme-Linked Immunosorbent Assay (ELISA) for the Determination of Mucin Levels in Bronchoalveolar Lavage Fluid. J. Pharm. Tox. Methods., 53:160-167

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Chao, J., A.G. Taveras, J. Chao, C. Aki, M. Dwyer, Y. Yu, B. Purakkattle, D. Rindgen, J. Jakway, W. Hipkin, J. Fosetta, X. Fan, D. Lundell, J. Fine, M. Minnicozzi, J. Phillips, and J.R. Merritt. 2007, C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable, CXCR2 and CXCR1 receptor antagonists. Bioorg. Med. Chem. Lett., 17:3778-3783

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Chapman, R.W., M. Minnicozzi, C.S. Celly, J.E. Phillips, T.T. Kung, R.W. Hipkin, X. Fan, D. Rindgen, G. Deno, R. Bond, W. Gonsiorek, M.M. Billah, J.S. Fine, and J.A. Hey. 2007, A Novel, Orally Active CXCR1/2 Receptor Antagonist, Sch527123, Inhibits Neutrophil Recruitment, Mucus Production, and Goblet Cell Hyperplasia in Animal Models of Pulmonary Inflammation. J. Pharmacol. Exp. Ther., 322:486-493

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Chapman, R.W., A. House, H. Jones, J. Richard, C.S. Celly, D. Prelusky, P. Ting, J.C. Hunter, J. Lamca, and J.E. Phillips. 2007, Effect of Inhaled Roflumilast on the Prevention and Resolution of Allergen-Induced Late Phase Airflow Obstruction in Brown Norway Rats. Eur. J. Pharmacol., 571:215-221

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Corboz, M.R., J.E. Phillips, and L. deGaravilla. 2008, Upper Airway Disease: Clinical Research and Prospectives. Pulm. Pharmacol. Ther., 21:431-432.

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Abbondanzo, S.J., D.J. Manfra, S. Chen, M. Pinzon-Ortiz, Y. Sun, J.E. Phillips, M. Laverty, G. Vassileva, W. Hu, S. Yang, E.L. Gustafson, J.S. Fine, and J.A. Hedrick. 2009, Nmur1-/- Mice are Not Protected from Cutaneous Inflammation. Biochem. Biophys. Res. Commun., 378:777-782

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Natiello, M., G. Kelly, J. Lamca, D. Zelmanovic, R.W. Chapman, and J.E. Phillips. 2009, Manual and Automated Leukocyte Differentiation in Bronchoalveolar Lavage Fluids from Rodent Models of Pulmonary Inflammation. Comp. Clin. Pathol., 18:101-111.

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Anthes, J.C., R.L. McLeod, R.W. Chapman, Y. Jia, A. House, X. Fernandez, J. Diaz, J. Jimenez, J. Richard, H. Jones, G. Kelly, M. Natiello, A. Curran, and J.E. Phillips. 2009, Changes in Upper and Lower Airway Inflammation Following Administration of Mometasone Furoate in Allergen-Challenged Brown Norway Rats. Arzneim. Forsch. Drug Res., 59:13-20.

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Chapman, R.W., J.E. Phillips, R.W. Hipkin, A. Curran, D. Lundell, and J.S. Fine. 2009, CXCR2 Antagonists for the Treatment of Pulmonary Disease. Pharmacol. Ther.., 121:55-68.

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Phillips, J.E., L. Ji, M. Rivelli, R.W. Chapman, and M.R. Corboz. 2009, Three-Dimensional Imaging and Morphometric Analysis of Rodent Paranasal Sinus Cavities from X-ray Computed Tomography. Can. J. Vet. Res.., (In Press).

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Invited Symposium Speaker

Formulation, Generation, and Delivery of Respiratory Therapeutic Aerosols to Rodents. � International Quality and Productivity Center (IQPC) Respiratory Drug Discovery and Development Conference on Asthma and COPD, Philadelphia, PA, 2009.

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Cigarette Smoke Induced Mouse-Models of COPD � SMi Group Conference on COPD: Novel Therapeutics and Management Strategies, Munich, Germany, 2009.

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Extra-Curricular Activities

Treasurer for the Chemical Engineering Graduate Students Association (ChEGSA) at the University of Illinois Chicago (1995).

Served on AIChE National Annual Meeting General Arrangements Committee in Chicago (1996).

Volunteer organizer for Friends of the Parks' L.A.T.E. Ride that raises money to protect and improve Chicago's parks and lakefront (1997-1998).

Classic Forum Moderator at the MUSTANGWORKS

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