Mutagenesis of dopamine receptors
Neve KA, Cox BA, Henningsen RA, Spanoyannis A, and Neve RL, Pivotal role for
aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and
inhibition of adenylyl cyclase. Mol. Pharmacol. 39:733-739, 1991. PubMed
Cox BA, Henningsen RA, Spanoyannis A, Neve RL, and Neve KA, Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors. J. Neurochem. 59:627-635, 1992. PubMed
Kozell LB, Machida CA, Neve RL, and Neve KA, Chimeric D1/D2 dopamine receptors: Distinct determinants of selective potency, efficacy, and signal transduction. J. Biol. Chem. 269:30299-30306, 1994. PubMed
Kozell LB and Neve KA, Constitutive activity of a chimeric D2/D1 dopamine receptor. Mol. Pharmacol. 52:1137-1149, 1997. PDF
Wiens BL, Nelson CS, and Neve KA, Contribution of serine residues to constitutive and agonist-induced signaling via the D2S dopamine receptor: evidence for multiple, agonist-specific active conformations. Mol. Pharmacol. 54:435-444, 1998. PDF
Wilcox RE, Huang W-H, Wilcox DM, Brusniak M-YK, Pearlman RS, Teeter MM, DuRand CJ, Wiens BL, and Neve KA, CoMFA-based prediction of agonist affinities at recombinant wildtype vs. serine to alanine point mutated D2 dopamine receptors. J. Med. Chem. 43:3005-3019, 2000. PDF
Neve KA, Cumbay MG, Thompson KR, Yang R, Buck DC, Watts VJ, DuRand CJ, and Teeter MM, Modeling and mutational analysis of a putative sodium-binding pocket on the dopamine D2 receptor. Mol. Pharmacol. 60:373-381, 2001. PubMed
Lan H, DuRand CJ, Teeter MM, and Neve KA, Structural determinants of pharmacological specificity between D1 and D2 dopamine receptors. Mol. Pharmacol. 69:185-194, 2006. PubMed
Liu Y, Teeter MM, DuRand CJ, and Neve KA, Identification of a Zn2+ binding site on the dopamine D2 receptor. Biochem. Biophys. Res. Comm. 339:873-879, 2006. PubMed
Dopamine receptor regulation
Neve KA, Neve RL, Fidel S, Janowsky A, and Higgins GA, Increased abundance of
alternatively spliced variants of dopamine D2 receptor mRNA after denervation. Proc.
Natl. Acad Sci. 88:5602-5608, 1991. PDF
Janowsky A, Neve KA, Kinzie JM, Taylor B, de Paulis T, and Belknap JK, Extrastriatal dopamine D2 receptors: distribution, pharmacological characterization, and region-specific regulation by clozapine. J. Pharmacol. Exp. Ther. 261:1281-1290, 1992. PubMed
Starr S, Kozell LB, and Neve KA, Drug-induced up-regulation of dopamine D2 receptors on cultured cells. J. Neurochem. 65:569-577, 1995. PubMed
Cox BA, Rosser MP, Kozlowski MR, Duwe KM, Neve RL, and Neve KA, Regulation and functional characterization of a rat recombinant dopamine D3 receptor. Synapse 21:1-9, 1995. PubMed
Watts VJ and Neve KA, Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors. Mol. Pharmacol. 50:966-976, 1996. PubMed
Watts VJ, Vu MN, Wiens BL, Jovanovic V, Van Tol HHM, and Neve KA, Short- and long-term heterologous sensitization of adenylate cyclase by D4 dopamine receptors. Psychopharmacology 141:83-92, 1999. PubMed
Watts VJ, Wiens BL, Cumbay MG, Vu M, Neve RL, and Neve KA, Selective activation of Gao by D2L dopamine receptors in NS20Y neuroblastoma cells. J. Neurosci. 18:8692-8699, 1998. PDF
Watts VJ, Taussig R, Neve RL, and Neve KA, Dopamine D2 receptor-induced heterologous sensitization of adenylate cyclase requires Gas: Characterization of Gas-insensitive mutants of adenylate cyclase V. Mol. Pharmacol. 60:1168-1172, 2001. PubMed
Mason JN, Kozell LB, and Neve KA, Regulation of dopamine D1 receptor trafficking by protein kinase A-dependent phosphorylation. Mol. Pharmacol. 61:806-816, 2002. PubMed
Macey TA, Gurevich VV, and Neve KA, Preferential interaction between the dopamine D2 receptor and arrestin2 in neostriatal neurons. Mol. Pharmacol. 66:1635-1642, 2004. PDF
Macey TA, Liu Y, Gurevich VV, and Neve KA, Dopamine D1 receptor interaction with arrestin3 in neostriatal neurons. J. Neurochem. 93:128-134, 2005. PubMed
Dopamine receptors, other
Bunzow JR, Van Tol HHM, Grandy DK, Albert P, Salon J, Christie M, Machida CA,
Neve KA, and Civelli O, Cloning and expression of a rat D2 dopamine receptor
cDNA. Nature 336:783-787, 1988. PubMed
Neve KA, Henningsen RA, Bunzow JR, and Civelli O, Functional characterization of a rat dopamine D-2 receptor cDNA expressed in a mammalian cell line. Mol. Pharmacol. 36:446-451, 1989. PubMed
Neve KA, Henningsen RA, Kinzie JM, de Paulis T, Schmidt DE, Kessler RM, and Janowsky A, Sodium-dependent isomerization of dopamine D-2 receptors characterized using [125I]epidepride, a high-affinity substituted benzamide ligand. J. Pharmacol. Exp. Ther. 252:1108-1116, 1990. PubMed
Joyce JN, Janowsky A, and Neve KA, Characterization and distribution of [125I]-epidepride binding to dopamine D2 receptors in basal ganglia and cortex of human brain. J. Pharmacol. Exp. Ther. 257:1253-1263, 1991. PubMed
Neve KA, Regulation of dopamine D2 receptors by sodium and pH. Mol. Pharmacol. 39:570-578, 1991. PubMed
Machida CA, Searles RP, Nipper V, Kozell LB, and Neve KA, Molecular cloning and expression of the rhesus macaque D1 dopamine receptor gene. Mol. Pharmacol. 41:652-659, 1992. PubMed
Neve KA, Kozlowski MR, and Rosser MP, Dopamine D2 receptor stimulation of Na+/H+ exchange assessed by quantification of extracellular acidification. J. Biol. Chem. 267:25748-25753, 1992. PubMed
Brusniak M-YK, Pearlman RS, Neve KA, and Wilcox RE, CoMFA-based prediction of drug affinities at recombinant D1A dopamine receptors. J. Med. Chem. 39:850-859, 1996. PubMed
Watts VJ and Neve KA, Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors. Mol. Pharmacol. 52:181-186, 1997. PDF
Luo Y, Kokkonen GC, Wang X, Neve KA, and Roth GS, D2 dopamine receptors stimulate mitogenesis through pertussis toxin-sensitive G proteins and ras-involved ERK and SAP/JNK pathways in rat C6-D2L glioma cells. J. Neurochem. 71:980-990, 1998. PubMed
Wilcox RE, Ginsburg B, Tseng T, Brusniak M-Y K, Pearlman RS, Teeter M, DuRand C, Starr S, and Neve KA, CoMFA-based prediction of agonist affinities at recombinant D1 vs. D2 dopamine receptors. J. Med. Chem. 41:4385-4399, 1998. PubMed
Wang C, Buck DC, Yang R, Macey TA, and Neve KA, Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases. J. Neurochem. 93:899-909, 2005. PubMed
Dopamine transporter
Eshleman AJ, Henningsen RA, Neve KA, and Janowsky A, Release of dopamine via
the human transporter. Mol. Pharmacol. 45:312-316, 1994. PubMed
Eshleman AJ, Neve RL, Janowsky A, and Neve KA, Characterization of a recombinant human dopamine transporter expressed in multiple cell lines. J. Pharmacol. Exp. Ther. 274:276-283, 1995. PubMed
Eshleman AJ, Stewart E, Evenson AK, Janowsky A, and Neve KA, Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters. J. Neurochem. 69:1459-1466, 1997. PubMed
Johnson RA, Eshleman AJ, Myers T, Neve KA, and Janowsky A, [3H]Substrate- and cell-specific effect of uptake inhibitors on human dopamine and serotonin transporter-mediated efflux. Synapse 30:97-106, 1998. PubMed
Eshleman AJ, Carmolli M, Cumbay M, Neve KA, and Janowsky A, Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type. J. Pharmacol. Exp. Ther. 289:877-885, 1999. PubMed
Recent Reviews
Neve KA, DuRand CJ, and Teeter MM, Structural analysis of the mammalian D2, D3,
and D4 dopamine receptors. In: Dopamine Receptors and Transporters: Function, Imaging, and
Clinical Implication (Sidhu A, Laruelle M, and Vernier P, editors.), Marcel
Dekker, Inc. (2003) 77-144.
Neve KA, Dopamine Receptors. In: Dopamine and Glutamate in Psychiatric Disorders (Reith MEA and Schmidt WJ, Eds.) Humana Press (2005) pp. 3-43.
Neve KA, Dopamine Receptors. In: Encyclopedia of Biological Chemistry (Lennarz WJ and Lane MD, Eds.), Elsevier, Oxford (2004) Vol. 1, pp. 817-822.
Neve KA, Seamans JK, and Trantham-Davidson H, Dopamine receptor signaling. Journal of Receptors and Signal Transduction 24 (2004) 165-205. PDF
Watts VJ and Neve KA, Sensitization of adenylate cyclase by Gai/o-coupled receptors. Pharmacology & Therapeutics 106 (2005) 405-421.PDF
Neve KA, Double feature at the signalplex. Molecular Pharmacology 68 (2005) 275-278.PDF
Neve KA, Novel features of G protein-coupled receptor kinase 4. Molecular Pharmacology 69 (2006) 673-676.PDF
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