| FBS vs FBS | WEEK 10 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 1-Nov | @ Ohio | 40.3 | Eastern Michigan | 25.0 | 15.23 |
| 1-Nov | Virginia Tech | 32.3 | @ Miami-Florida | 28.7 | 3.54 |
| 1-Nov | @ Western Kentucky | 36.3 | Middle Tennessee | 23.3 | 13.02 |
| 2-Nov | @ California | 31.6 | Washington | 23.7 | 7.95 |
| 3-Nov | Air Force | 43.1 | @ Army | 30.3 | 12.86 |
| 3-Nov | Alabama | 28.7 | @ L S U | 12.4 | 16.26 |
| 3-Nov | @ Arkansas | 39.1 | Tulsa | 29.5 | 9.60 |
| 3-Nov | Arkansas State | 33.5 | @ North Texas | 29.7 | 3.83 |
| 3-Nov | @ Auburn | 36.6 | New Mexico State | 17.3 | 19.33 |
| 3-Nov | @ Baylor | 46.6 | Kansas | 36.1 | 10.47 |
| 3-Nov | @ Boise State | 36.3 | San Diego State | 19.6 | 16.72 |
| 3-Nov | @ Buffalo | 35.8 | Miami-Ohio | 25.2 | 10.66 |
| 3-Nov | @ Central Florida | 34.3 | S M U | 24.9 | 9.44 |
| 3-Nov | Clemson | 42.5 | @ Duke | 29.6 | 12.90 |
| 3-Nov | @ Florida | 30.5 | Missouri | 7.9 | 22.64 |
| 3-Nov | @ Fresno State | 51.8 | Hawaii | 13.4 | 38.41 |
| 3-Nov | @ Georgia | 36.8 | Mississippi | 25.3 | 11.54 |
| 3-Nov | Houston | 37.3 | @ East Carolina | 34.7 | 2.58 |
| 3-Nov | @ Indiana | 32.0 | Iowa | 24.8 | 7.26 |
| 3-Nov | @ Kansas State | 41.4 | Oklahoma State | 32.5 | 8.90 |
| 3-Nov | @ Kent State | 44.9 | Akron | 22.4 | 22.43 |
| 3-Nov | @ La-Monroe | 46.0 | La-Lafayette | 26.7 | 19.33 |
| 3-Nov | @ Louisiana Tech | 55.9 | U T S A | 25.0 | 30.80 |
| 3-Nov | @ Louisville | 38.2 | Temple | 13.9 | 24.33 |
| 3-Nov | @ Marshall | 49.5 | Memphis | 24.9 | 24.59 |
| 3-Nov | @ Maryland | 28.4 | Georgia Tech | 25.6 | 2.82 |
| 3-Nov | Michigan | 30.0 | @ Minnesota | 14.5 | 15.54 |
| 3-Nov | @ Navy | 30.8 | Florida Atlantic | 19.3 | 11.46 |
| 3-Nov | Nebraska | 25.6 | @ Michigan State | 22.8 | 2.78 |
| 3-Nov | New Mexico | 32.7 | @ U N L V | 32.2 | 0.47 |
| 3-Nov | @ North Carolina St | 35.4 | Virginia | 22.1 | 13.27 |
| 3-Nov | @ Northern Illinois | 51.5 | Massachusetts | 8.0 | 43.51 |
| 3-Nov | @ Notre Dame | 33.1 | Pittsburgh | 10.9 | 22.22 |
| 3-Nov | @ Ohio State | 41.5 | Illinois | 13.4 | 28.12 |
| 3-Nov | Oklahoma | 37.2 | @ Iowa State | 19.3 | 17.87 |
| 3-Nov | Oregon | 40.7 | @ U S C | 31.9 | 8.76 |
| 3-Nov | @ Oregon State | 30.0 | Arizona State | 25.7 | 4.24 |
| 3-Nov | Penn State | 32.9 | @ Purdue | 21.1 | 11.79 |
| 3-Nov | Rice | 39.7 | @ Tulane | 26.5 | 13.21 |
| 3-Nov | San Jose State | 48.3 | @ Idaho | 13.0 | 35.28 |
| 3-Nov | @ South Alabama | 29.1 | Florida Int'l | 24.1 | 5.00 |
| 3-Nov | @ South Florida | 29.4 | Connecticut | 16.7 | 12.68 |
| 3-Nov | @ Southern Miss | 35.4 | U A B | 34.6 | 0.83 |
| 3-Nov | Stanford | 43.2 | @ Colorado | 14.5 | 28.69 |
| 3-Nov | Syracuse | 30.5 | @ Cincinnati | 27.4 | 3.14 |
| 3-Nov | T C U | 44.3 | @ West Virginia | 34.6 | 9.71 |
| 3-Nov | @ Tennessee | 41.1 | Troy | 29.9 | 11.19 |
| 3-Nov | Texas A&M | 37.8 | @ Mississippi State | 27.6 | 10.23 |
| 3-Nov | @ Texas Tech | 49.2 | Texas | 29.0 | 20.24 |
| 3-Nov | @ U C L A | 42.3 | Arizona | 38.0 | 4.28 |
| 3-Nov | @ Utah | 30.6 | Washington State | 19.7 | 10.87 |
| 3-Nov | @ Utah State | 44.1 | Texas State | 11.7 | 32.37 |
| 3-Nov | Vanderbilt | 26.5 | @ Kentucky | 19.0 | 7.50 |
| 3-Nov | @ Wake Forest | 31.5 | Boston College | 24.4 | 7.13 |
| 3-Nov | Western Michigan | 38.6 | @ Central Michigan | 29.8 | 8.77 |
| 3-Nov | @ Wyoming | 31.2 | Colorado State | 26.7 | 4.55 |
| FCS vs FCS | WEEK 10 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 3-Nov | @ Alabama A&M | 31.5 | Southern U | 12.7 | 18.81 |
| 3-Nov | Alabama State | 32.9 | @ Prairie View | 27.0 | 5.88 |
| 3-Nov | @ Albany-NY | 31.9 | Wagner | 10.9 | 20.97 |
| 3-Nov | Arkansas-Pine Bluff | 34.2 | @ Texas Southern | 11.6 | 22.56 |
| 3-Nov | Bethune-Cookman | 37.7 | @ Morgan State | 15.4 | 22.31 |
| 3-Nov | @ Brown | 31.1 | Yale | 13.9 | 17.20 |
| 3-Nov | @ Campbell | 34.3 | Valparaiso | 30.1 | 4.23 |
| 3-Nov | @ Central Arkansas | 37.6 | Northwestern State | 19.7 | 17.88 |
| 3-Nov | Chattanooga | 39.8 | @ Western Carolina | 18.1 | 21.79 |
| 3-Nov | Coastal Carolina | 35.5 | @ Gardner-Webb | 24.4 | 11.15 |
| 3-Nov | @ Colgate | 39.5 | Lafayette | 18.9 | 20.59 |
| 3-Nov | @ Cornell | 27.1 | Dartmouth | 25.2 | 1.91 |
| 3-Nov | Delaware State | 24.4 | @ N C Central | 22.0 | 2.32 |
| 3-Nov | Drake | 25.0 | @ Dayton | 22.1 | 2.93 |
| 3-Nov | Duquesne | 28.3 | @ Robert Morris | 21.0 | 7.35 |
| 3-Nov | Eastern Illinois | 52.3 | @ Tennessee Tech | 30.5 | 21.78 |
| 3-Nov | Eastern Kentucky | 37.0 | @ SE Missouri State | 23.3 | 13.72 |
| 3-Nov | @ Eastern Wash | 33.3 | Cal Poly | 29.6 | 3.65 |
| 3-Nov | Fordham | 27.6 | @ Bucknell | 21.5 | 6.18 |
| 3-Nov | @ Georgia Southern | 37.0 | Appalachian State | 23.4 | 13.60 |
| 3-Nov | @ Harvard | 41.9 | Columbia | 7.8 | 34.09 |
| 3-Nov | @ Howard | 26.5 | Hampton | 22.4 | 4.06 |
| 3-Nov | @ Indiana State | 22.1 | Illinois State | 18.7 | 3.39 |
| 3-Nov | Jackson State | 32.3 | @ Grambling | 15.8 | 16.54 |
| 3-Nov | Jacksonville | 25.4 | @ Butler | 23.3 | 2.09 |
| 3-Nov | Jacksonville State | 36.0 | @ Tennessee-Martin | 31.8 | 4.20 |
| 3-Nov | Lehigh | 33.6 | @ Holy Cross | 15.3 | 18.37 |
| 3-Nov | @ Liberty | 35.5 | Charleston Southern | 14.5 | 21.01 |
| 3-Nov | @ Maine | 25.1 | James Madison | 21.3 | 3.81 |
| 3-Nov | McNeese State | 32.3 | @ Nicholls State | 25.5 | 6.80 |
| 3-Nov | @ Mississippi Valley | 21.6 | Alcorn State | 11.8 | 9.81 |
| 3-Nov | @ Monmouth | 34.0 | Central Connecticut | 24.3 | 9.69 |
| 3-Nov | Montana | 34.3 | @ Weber State | 30.2 | 4.11 |
| 3-Nov | Montana State | 40.8 | @ Sacramento State | 19.8 | 21.01 |
| 3-Nov | @ Morehead State | 41.1 | Davidson | 21.7 | 19.32 |
| 3-Nov | @ Murray State | 39.5 | Tennessee State | 35.7 | 3.73 |
| 3-Nov | @ New Hampshire | 35.6 | William & Mary | 21.1 | 14.48 |
| 3-Nov | @ Norfolk State | 37.2 | Savannah State | 13.3 | 23.87 |
| 3-Nov | @ North Carolina A&T | 20.8 | Florida A&M | 20.8 | 0.05 |
| 3-Nov | North Dakota State | 29.7 | @ Missouri State | 9.7 | 20.00 |
| 3-Nov | Northern Arizona | 54.2 | @ Idaho State | 18.6 | 35.60 |
| 3-Nov | Northern Iowa | 29.8 | @ Western Illinois | 12.5 | 17.30 |
| 3-Nov | Old Dominion | 46.7 | @ Georgia State | 25.0 | 21.69 |
| 3-Nov | @ Portland State | 42.7 | Northern Colorado | 21.8 | 20.92 |
| 3-Nov | @ Princeton | 30.2 | Pennsylvania | 17.4 | 12.77 |
| 3-Nov | @ Richmond | 45.4 | Rhode Island | 11.6 | 33.75 |
| 3-Nov | Sacred Heart | 23.8 | @ Bryant | 23.4 | 0.37 |
| 3-Nov | @ Sam Houston State | 48.7 | SE Louisiana | 6.0 | 42.65 |
| 3-Nov | San Diego | 30.5 | @ Marist | 17.1 | 13.39 |
| 3-Nov | South Dakota State | 20.3 | @ Southern Illinois | 19.3 | 0.94 |
| 3-Nov | Southern Utah | 37.6 | @ North Dakota | 34.1 | 3.44 |
| 3-Nov | @ Stephen F Austin | 49.3 | Lamar | 10.3 | 38.91 |
| 3-Nov | @ Stony Brook | 47.2 | V M I | 2.3 | 44.94 |
| 3-Nov | @ The Citadel | 33.6 | Elon | 27.4 | 6.26 |
| 3-Nov | Towson | 34.3 | @ Delaware | 17.6 | 16.75 |
| 3-Nov | Wofford | 26.9 | @ Samford | 26.0 | 0.94 |
| 3-Nov | @ Youngstown State | 36.3 | South Dakota | 19.8 | 16.48 |
| FCS vs Non D-I | WEEK 10 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 3-Nov | @ Austin Peay | 42.4 | Culver-Stockton | 12.2 | 30.26 |