| FBS vs FBS | WEEK 12 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 14-Nov | @ Ball State | 40.9 | Ohio | 31.2 | 9.69 |
| 14-Nov | @ Northern Illinois | 45.7 | Toledo | 25.6 | 20.07 |
| 15-Nov | @ Virginia | 34.2 | North Carolina | 32.4 | 1.87 |
| 16-Nov | @ Air Force | 43.5 | Hawaii | 22.5 | 21.02 |
| 16-Nov | @ Florida Atlantic | 30.8 | Florida Int'l | 23.8 | 7.01 |
| 17-Nov | @ Arizona State | 40.5 | Washington State | 21.3 | 19.23 |
| 17-Nov | @ Army | 34.4 | Temple | 24.2 | 10.19 |
| 17-Nov | @ Boise State | 36.5 | Colorado State | 11.5 | 25.04 |
| 17-Nov | @ Bowling Green | 28.3 | Kent State | 21.1 | 7.18 |
| 17-Nov | Brigham Young | 26.6 | @ San Jose State | 21.8 | 4.86 |
| 17-Nov | Buffalo | 34.6 | @ Massachusetts | 19.3 | 15.36 |
| 17-Nov | @ Central Michigan | 37.6 | Miami-Ohio | 33.1 | 4.54 |
| 17-Nov | @ Cincinnati | 28.2 | Rutgers | 18.7 | 9.48 |
| 17-Nov | @ Clemson | 45.3 | North Carolina State | 20.7 | 24.64 |
| 17-Nov | East Carolina | 39.1 | @ Tulane | 24.7 | 14.50 |
| 17-Nov | Florida State | 39.2 | @ Maryland | 9.3 | 29.85 |
| 17-Nov | @ Georgia Tech | 45.4 | Duke | 28.2 | 17.15 |
| 17-Nov | @ Kansas | 29.7 | Iowa State | 25.2 | 4.42 |
| 17-Nov | Kansas State | 46.0 | @ Baylor | 38.8 | 7.26 |
| 17-Nov | @ L S U | 35.0 | Mississippi | 15.7 | 19.23 |
| 17-Nov | @ La-Lafayette | 33.8 | Western Kentucky | 27.9 | 5.96 |
| 17-Nov | @ La-Monroe | 38.1 | North Texas | 26.3 | 11.76 |
| 17-Nov | @ Marshall | 48.7 | Houston | 39.4 | 9.27 |
| 17-Nov | @ Miami-Florida | 33.0 | South Florida | 29.8 | 3.23 |
| 17-Nov | @ Michigan | 36.6 | Iowa | 7.0 | 29.56 |
| 17-Nov | @ Michigan State | 26.4 | Northwestern | 18.5 | 7.88 |
| 17-Nov | @ Mississippi State | 29.8 | Arkansas | 26.8 | 3.02 |
| 17-Nov | @ Missouri | 28.4 | Syracuse | 27.0 | 1.39 |
| 17-Nov | @ Navy | 40.9 | Texas State | 20.7 | 20.19 |
| 17-Nov | @ Nebraska | 40.3 | Minnesota | 15.6 | 24.79 |
| 17-Nov | Nevada | 41.8 | @ New Mexico | 33.3 | 8.43 |
| 17-Nov | @ Notre Dame | 40.1 | Wake Forest | 2.3 | 37.89 |
| 17-Nov | Oklahoma | 49.7 | @ West Virginia | 31.6 | 18.08 |
| 17-Nov | @ Oklahoma State | 44.1 | Texas Tech | 36.3 | 7.80 |
| 17-Nov | @ Oregon | 44.4 | Stanford | 23.6 | 20.73 |
| 17-Nov | @ Oregon State | 37.3 | California | 17.5 | 19.74 |
| 17-Nov | @ Penn State | 43.2 | Indiana | 16.7 | 26.51 |
| 17-Nov | Purdue | 30.6 | @ Illinois | 22.4 | 8.28 |
| 17-Nov | S M U | 34.9 | @ Rice | 30.6 | 4.30 |
| 17-Nov | @ South Alabama | 28.4 | Middle Tennessee | 28.3 | 0.09 |
| 17-Nov | Texas-El Paso | 31.6 | @ Southern Miss | 24.4 | 7.22 |
| 17-Nov | @ Troy | 37.4 | Arkansas State | 36.6 | 0.80 |
| 17-Nov | @ Tulsa | 32.8 | Central Florida | 29.8 | 2.94 |
| 17-Nov | @ U A B | 38.9 | Memphis | 24.9 | 13.98 |
| 17-Nov | @ U C L A | 36.0 | U S C | 35.8 | 0.23 |
| 17-Nov | @ U N L V | 35.7 | Wyoming | 29.5 | 6.21 |
| 17-Nov | U T S A | 35.4 | @ Idaho | 25.5 | 9.84 |
| 17-Nov | @ Utah | 37.4 | Arizona | 30.5 | 6.93 |
| 17-Nov | Utah State | 43.3 | @ Louisiana Tech | 37.0 | 6.31 |
| 17-Nov | @ Vanderbilt | 35.0 | Tennessee | 30.9 | 4.04 |
| 17-Nov | Virginia Tech | 35.0 | @ Boston College | 19.1 | 15.88 |
| 17-Nov | Washington | 41.0 | @ Colorado | 17.7 | 23.36 |
| 17-Nov | @ Western Michigan | 44.6 | Eastern Michigan | 22.7 | 21.85 |
| 17-Nov | @ Wisconsin | 32.0 | Ohio State | 24.4 | 7.59 |
| FBS vs FCS | WEEK 12 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 17-Nov | @ Alabama | 70.7 | Western Carolina | 0.0 | 70.71 |
| 17-Nov | @ Auburn | 36.9 | Alabama A&M | 6.0 | 30.81 |
| 17-Nov | @ Florida | 47.3 | Jacksonville State | 5.8 | 41.43 |
| 17-Nov | @ Georgia | 43.3 | Georgia Southern | 16.5 | 26.84 |
| 17-Nov | Samford | 24.6 | @ Kentucky | 22.0 | 2.57 |
| 17-Nov | @ South Carolina | 38.4 | Wofford | 11.1 | 27.27 |
| 17-Nov | @ Texas A&M | 46.1 | Sam Houston State | 25.0 | 21.15 |
| FCS vs FCS | WEEK 12 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 15-Nov | @ Nicholls State | 27.9 | SE Louisiana | 27.6 | 0.35 |
| 17-Nov | @ Albany-NY | 36.7 | Central Connecticut | 18.2 | 18.50 |
| 17-Nov | @ Arkansas-Pine Bluff | 33.6 | Prairie View | 19.6 | 14.00 |
| 17-Nov | Bethune-Cookman | 27.5 | Florida A&M | 17.7 | 9.74 |
| 17-Nov | @ Brown | 28.8 | Columbia | 10.6 | 18.14 |
| 17-Nov | @ Bucknell | 23.7 | Bryant | 21.3 | 2.34 |
| 17-Nov | @ Central Arkansas | 38.0 | Eastern Illinois | 33.8 | 4.20 |
| 17-Nov | @ Chattanooga | 33.7 | Elon | 16.6 | 17.15 |
| 17-Nov | @ Coastal Carolina | 40.0 | Charleston Southern | 16.8 | 23.18 |
| 17-Nov | Colgate | 41.8 | @ Fordham | 30.7 | 11.09 |
| 17-Nov | Delaware State | 26.3 | @ Howard | 20.8 | 5.47 |
| 17-Nov | Drake | 24.2 | @ Jacksonville | 21.2 | 2.97 |
| 17-Nov | Eastern Washington | 34.6 | @ Portland State | 34.3 | 0.26 |
| 17-Nov | @ Furman | 32.1 | The Citadel | 26.2 | 5.87 |
| 17-Nov | @ Gardner-Webb | 41.3 | Presbyterian | 18.8 | 22.44 |
| 17-Nov | @ Georgetown | 25.9 | Holy Cross | 23.2 | 2.68 |
| 17-Nov | Hampton | 25.5 | @ Morgan State | 23.9 | 1.53 |
| 17-Nov | @ Harvard | 45.1 | Yale | 8.5 | 36.55 |
| 17-Nov | Jackson State | 35.9 | @ Alcorn State | 14.4 | 21.52 |
| 17-Nov | Lehigh | 28.8 | @ Lafayette | 23.8 | 5.01 |
| 17-Nov | Liberty | 33.6 | @ V M I | 10.0 | 23.60 |
| 17-Nov | Maine | 35.2 | @ Rhode Island | 10.4 | 24.87 |
| 17-Nov | Marist | 40.8 | @ Campbell | 9.8 | 31.05 |
| 17-Nov | @ McNeese State | 37.2 | Lamar | 15.0 | 22.25 |
| 17-Nov | Mississippi Valley | 27.7 | @ Texas Southern | 11.2 | 16.43 |
| 17-Nov | Monmouth | 25.4 | @ Robert Morris | 25.3 | 0.05 |
| 17-Nov | Montana State | 37.4 | @ Montana | 28.1 | 9.30 |
| 17-Nov | @ Morehead State | 53.1 | Valparaiso | 19.8 | 33.31 |
| 17-Nov | @ Murray State | 48.7 | SE Missouri State | 31.3 | 17.34 |
| 17-Nov | North Carolina A&T | 23.0 | @ N C Central | 16.3 | 6.70 |
| 17-Nov | North Dakota State | 27.1 | @ Illinois State | 14.0 | 13.05 |
| 17-Nov | @ Northern Arizona | 33.8 | Cal Poly | 28.4 | 5.40 |
| 17-Nov | @ Northern Colorado | 37.7 | North Dakota | 30.9 | 6.83 |
| 17-Nov | @ Northern Iowa | 26.2 | Missouri State | 18.2 | 7.94 |
| 17-Nov | Old Dominion | 34.4 | @ James Madison | 33.1 | 1.30 |
| 17-Nov | Pennsylvania | 33.0 | @ Cornell | 24.7 | 8.33 |
| 17-Nov | @ Princeton | 25.2 | Dartmouth | 19.7 | 5.44 |
| 17-Nov | Richmond | 27.3 | @ William & Mary | 24.8 | 2.42 |
| 17-Nov | Samford | 24.6 | @ Kentucky | 22.0 | 2.57 |
| 17-Nov | San Diego | 41.7 | @ Davidson | 11.1 | 30.65 |
| 17-Nov | @ South Carolina St | 42.3 | Savannah State | 11.6 | 30.70 |
| 17-Nov | @ South Dakota State | 30.7 | South Dakota | 9.8 | 20.85 |
| 17-Nov | @ Southern Illinois | 29.5 | Western Illinois | 4.7 | 24.86 |
| 17-Nov | @ St Francis PA | 29.0 | Sacred Heart | 19.9 | 9.15 |
| 17-Nov | @ Stephen F Austin | 44.6 | Northwestern State | 21.5 | 23.07 |
| 17-Nov | Tennessee State | 32.9 | @ Tennessee-Martin | 32.8 | 0.12 |
| 17-Nov | Tennessee Tech | 36.3 | @ Austin Peay | 34.3 | 1.94 |
| 17-Nov | Towson | 34.9 | @ New Hampshire | 30.2 | 4.66 |
| 17-Nov | @ UC-Davis | 30.1 | Sacramento State | 28.3 | 1.84 |
| 17-Nov | Villanova | 29.7 | @ Delaware | 22.1 | 7.62 |
| 17-Nov | @ Wagner | 26.0 | Duquesne | 18.2 | 7.79 |
| 17-Nov | Weber State | 48.3 | @ Idaho State | 27.5 | 20.75 |
| 17-Nov | @ Youngstown State | 22.8 | Indiana State | 20.3 | 2.49 |