| FBS vs FBS | WEEK 2 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 6-Sep | @ Cincinnati | 31.8 | Pittsburgh | 16.5 | 15.32 |
| 7-Sep | Utah | 27.7 | @ Utah State | 19.7 | 7.98 |
| 8-Sep | @ Alabama | 37.4 | Western Kentucky | 12.9 | 24.59 |
| 8-Sep | @ Arizona State | 27.0 | Illinois | 20.2 | 6.73 |
| 8-Sep | @ Arkansas | 48.2 | La-Monroe | 16.1 | 32.14 |
| 8-Sep | @ Arkansas State | 51.3 | Memphis | 20.9 | 30.35 |
| 8-Sep | Auburn | 25.5 | @ Mississippi State | 23.2 | 2.27 |
| 8-Sep | @ Bowling Green | 36.2 | Idaho | 4.4 | 31.76 |
| 8-Sep | @ Clemson | 47.6 | Ball State | 25.7 | 21.85 |
| 8-Sep | @ Connecticut | 28.1 | North Carolina State | 20.2 | 7.82 |
| 8-Sep | @ Florida Int'l | 50.9 | Akron | 7.6 | 43.27 |
| 8-Sep | Indiana | 26.2 | @ Massachusetts | 17.4 | 8.77 |
| 8-Sep | @ Iowa | 24.9 | Iowa State | 24.6 | 0.36 |
| 8-Sep | @ Kansas | 40.7 | Rice | 29.5 | 11.25 |
| 8-Sep | @ Kansas State | 46.0 | Miami-Florida | 21.3 | 24.74 |
| 8-Sep | @ Kentucky | 25.1 | Kent State | 19.5 | 5.66 |
| 8-Sep | @ L S U | 39.6 | Washington | 11.4 | 28.19 |
| 8-Sep | La-Lafayette | 37.1 | @ Troy | 28.5 | 8.54 |
| 8-Sep | Louisiana Tech | 31.0 | @ Houston | 30.9 | 0.06 |
| 8-Sep | @ Michigan | 46.3 | Air Force | 21.3 | 25.00 |
| 8-Sep | Michigan State | 33.7 | @ Central Michigan | 13.4 | 20.32 |
| 8-Sep | @ Middle Tennessee | 21.0 | Florida Atlantic | 17.7 | 3.28 |
| 8-Sep | @ Mississippi | 32.3 | Texas-El Paso | 23.1 | 9.29 |
| 8-Sep | @ Missouri | 33.5 | Georgia | 30.1 | 3.41 |
| 8-Sep | Nebraska | 36.2 | @ U C L A | 35.3 | 0.85 |
| 8-Sep | @ Nevada | 29.7 | South Florida | 25.2 | 4.52 |
| 8-Sep | North Carolina | 36.9 | @ Wake Forest | 14.6 | 22.30 |
| 8-Sep | @ Notre Dame | 30.2 | Purdue | 26.1 | 4.19 |
| 8-Sep | @ Ohio | 46.0 | New Mexico State | 16.4 | 29.63 |
| 8-Sep | @ Ohio State | 33.5 | Central Florida | 21.3 | 12.23 |
| 8-Sep | Oklahoma State | 51.0 | @ Arizona | 24.8 | 26.23 |
| 8-Sep | @ Oregon | 52.0 | Fresno State | 26.3 | 25.62 |
| 8-Sep | @ San Diego State | 32.3 | Army | 19.1 | 13.21 |
| 8-Sep | @ South Carolina | 35.7 | East Carolina | 8.2 | 27.54 |
| 8-Sep | @ Stanford | 38.5 | Duke | 18.7 | 19.78 |
| 8-Sep | @ Temple | 28.1 | Maryland | 7.7 | 20.45 |
| 8-Sep | @ Texas | 51.6 | New Mexico | 13.2 | 38.47 |
| 8-Sep | @ Texas A&M | 31.1 | Florida | 22.0 | 9.16 |
| 8-Sep | Texas Tech | 40.5 | @ Texas State | 17.2 | 23.32 |
| 8-Sep | @ Tulsa | 43.1 | Tulane | 13.7 | 29.38 |
| 8-Sep | U S C | 48.5 | Syracuse | 22.6 | 25.91 |
| 8-Sep | Vanderbilt | 35.8 | @ Northwestern | 23.5 | 12.30 |
| 8-Sep | @ Virginia | 33.0 | Penn State | 17.3 | 15.67 |
| 8-Sep | Wisconsin | 31.2 | @ Oregon State | 24.5 | 6.71 |
| 8-Sep | @ Wyoming | 35.1 | Toledo | 31.0 | 4.08 |
| FBS vs FCS | WEEK 2 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 8-Sep | @ Boston College | 35.5 | Maine | 21.9 | 13.60 |
| 8-Sep | @ Brigham Young | 44.3 | Weber State | 6.0 | 38.30 |
| 8-Sep | @ Buffalo | 38.8 | Morgan State | 18.8 | 20.02 |
| 8-Sep | @ California | 43.9 | Southern Utah | 11.8 | 32.01 |
| 8-Sep | @ Colorado | 34.4 | Sacramento State | 14.9 | 19.52 |
| 8-Sep | North Dakota State | 28.1 | @ Colorado State | 11.0 | 17.11 |
| 8-Sep | Illinois State | 30.8 | @ Eastern Michigan | 27.3 | 3.55 |
| 8-Sep | @ Florida State | 86.2 | Savannah State | 0.0 | 86.19 |
| 8-Sep | @ Georgia Tech | 42.9 | Presbyterian | 9.3 | 33.59 |
| 8-Sep | @ Louisville | 43.3 | Missouri State | 8.4 | 34.92 |
| 8-Sep | @ Marshall | 58.4 | Western Carolina | 27.5 | 30.85 |
| 8-Sep | @ Miami-Ohio | 44.0 | Southern Illinois | 24.7 | 19.25 |
| 8-Sep | @ Minnesota | 32.9 | New Hampshire | 27.2 | 5.71 |
| 8-Sep | @ North Texas | 48.9 | Texas Southern | 17.5 | 31.44 |
| 8-Sep | @ Northern Illinois | 36.6 | Tennessee-Martin | 10.6 | 26.01 |
| 8-Sep | @ Oklahoma | 57.9 | Florida A&M | 0.0 | 57.90 |
| 8-Sep | @ Rutgers | 55.4 | Howard | 0.0 | 55.42 |
| 8-Sep | @ S M U | 39.9 | Stephen F Austin | 31.0 | 8.94 |
| 8-Sep | @ San Jose State | 27.6 | UC-Davis | 14.4 | 13.22 |
| 8-Sep | @ South Alabama | 33.0 | Nicholls State | 16.0 | 17.07 |
| 8-Sep | @ T C U | 51.8 | Grambling | 5.9 | 45.86 |
| 8-Sep | @ Tennessee | 56.6 | Georgia State | 0.0 | 56.60 |
| 8-Sep | @ U N L V | 38.1 | Northern Arizona | 28.0 | 10.04 |
| 8-Sep | @ Virginia Tech | 55.0 | Austin Peay | 0.0 | 54.95 |
| 8-Sep | Eastern Washington | 26.0 | @ Washington State | 22.2 | 3.78 |
| 8-Sep | @ Western Michigan | 39.8 | Eastern Illinois | 20.2 | 19.54 |
| FCS vs FCS | WEEK 2 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 8-Sep | Alabama A&M | 17.1 | @ Arkansas-Pine Bluff | 11.0 | 6.08 |
| 8-Sep | @ Alabama State | 31.0 | Mississippi Valley | 11.6 | 19.45 |
| 8-Sep | Albany-NY | 37.9 | @ Robert Morris | 14.4 | 23.46 |
| 8-Sep | Bryant | 32.9 | @ St Francis PA | 29.9 | 3.08 |
| 8-Sep | Bucknell | 18.7 | @ Marist | 16.5 | 2.27 |
| 8-Sep | Central Arkansas | 43.5 | @ Murray State | 30.5 | 13.04 |
| 8-Sep | @ Charleston Southern | 27.4 | Jacksonville | 26.7 | 0.72 |
| 8-Sep | @ Delaware | 38.0 | Delaware State | 7.4 | 30.63 |
| 8-Sep | @ Duquesne | 35.5 | Dayton | 27.8 | 7.67 |
| 8-Sep | @ Eastern Kentucky | 44.3 | Morehead State | 19.8 | 24.51 |
| 8-Sep | @ Elon | 41.2 | NC Central | 18.8 | 22.32 |
| 8-Sep | @ Furman | 28.3 | Coastal Carolina | 18.1 | 10.15 |
| 8-Sep | @ Georgetown | 25.5 | Wagner | 9.8 | 15.66 |
| 8-Sep | Georgia Southern | 36.6 | @ The Citadel | 22.1 | 14.53 |
| 8-Sep | Jackson State | 28.2 | Tennessee State | 21.8 | 6.43 |
| 8-Sep | @ Jacksonville State | 29.0 | Chattanooga | 26.4 | 2.61 |
| 8-Sep | @ James Madison | 50.2 | Alcorn State | 0.0 | 50.15 |
| 8-Sep | Lehigh | 38.3 | @ Central Connecticut | 13.2 | 25.10 |
| 8-Sep | @ Liberty | 22.2 | Norfolk State | 10.6 | 11.61 |
| 8-Sep | @ Monmouth | 32.4 | Rhode Island | 17.6 | 14.81 |
| 8-Sep | Montana | 28.5 | @ Appalachian State | 27.6 | 0.94 |
| 8-Sep | Montana State | 27.5 | @ Drake | 8.7 | 18.77 |
| 8-Sep | @ North Dakota | 35.9 | Portland State | 24.1 | 11.84 |
| 8-Sep | Old Dominion | 52.4 | @ Hampton | 16.9 | 35.50 |
| 8-Sep | Prairie View | 32.4 | @ Lamar | 28.2 | 4.19 |
| 8-Sep | @ Richmond | 27.8 | Gardner-Webb | 21.9 | 5.90 |
| 8-Sep | @ South Carolina St | 34.9 | Bethune-Cookman | 24.5 | 10.34 |
| 8-Sep | @ South Dakota | 30.7 | Colgate | 28.8 | 1.88 |
| 8-Sep | South Dakota State | 40.7 | @ SE Louisiana | 24.4 | 16.29 |
| 8-Sep | @ Villanova | 29.0 | Fordham | 17.6 | 11.39 |
| 8-Sep | @ William & Mary | 26.5 | Lafayette | 8.6 | 17.92 |
| 8-Sep | @ Youngstown State | 64.3 | Valparaiso | 7.4 | 56.90 |
| FBS/FCS vs Non D-I | WEEK 2 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 6-Sep | @ Tennessee Tech | 36.9 | North Greenville | 19.3 | 17.62 |
| 8-Sep | @ Butler | 30.5 | Franklin | 19.1 | 11.39 |
| 8-Sep | @ Campbell | 34.3 | VA-Wise | 21.4 | 12.86 |
| 8-Sep | @ Lenoir-Rhyne | 33.0 | Davidson | 17.0 | 15.98 |
| 8-Sep | @ Idaho State | 41.6 | Black Hills St | 18.7 | 22.91 |
| 8-Sep | @ Indiana State | 48.7 | Quincy | 2.9 | 45.83 |
| 8-Sep | @ McNeese State | 42.1 | McMurry | 10.5 | 31.66 |
| 8-Sep | @ North Carolina A&T | 37.0 | West Virginia St | 11.6 | 25.33 |
| 8-Sep | @ Northern Colorado | 28.3 | Colorado Mesa | 21.9 | 6.37 |
| 8-Sep | @ Northern Iowa | 52.0 | Central State | 0.0 | 52.01 |
| 8-Sep | @ Northwestern State | 36.7 | Ark-Monticello | 13.5 | 23.19 |
| 8-Sep | @ Sam Houston State | 61.6 | Incarnate Word | 0.0 | 61.60 |
| 8-Sep | @ Samford | 33.5 | West Alabama | 18.7 | 14.80 |
| 8-Sep | @ San Diego | 35.4 | Western New Mexico | 17.6 | 17.88 |
| 8-Sep | @ SE Missouri State | 33.6 | Mars Hill | 22.2 | 11.49 |
| 8-Sep | @ Stony Brook | 66.8 | Pace | 0.0 | 66.76 |
| 8-Sep | @ U T S A | 43.1 | TA&M-Commerce | 9.0 | 34.15 |
| 8-Sep | @ V M I | 29.0 | Chowan | 17.2 | 11.84 |
| 8-Sep | @ Western Illinois | 26.3 | Indianapolis | 23.7 | 2.60 |
| 8-Sep | @ Wofford | 60.2 | Lincoln-PA | 0.0 | 60.21 |