| FBS vs FBS | WEEK 5 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 27-Sep | Stanford | 28.6 | @ Washington | 19.3 | 9.24 |
| 28-Sep | @ Brigham Young | 41.8 | Hawaii | 9.2 | 32.61 |
| 29-Sep | @ Air Force | 40.1 | Colorado State | 22.5 | 17.62 |
| 29-Sep | @ Akron | 36.8 | Miami-Ohio | 30.0 | 6.79 |
| 29-Sep | @ Alabama | 43.5 | Mississippi | 8.9 | 34.67 |
| 29-Sep | @ Arizona | 30.7 | Oregon State | 27.9 | 2.83 |
| 29-Sep | Arizona State | 37.2 | @ California | 24.6 | 12.62 |
| 29-Sep | @ Arkansas State | 32.8 | Western Kentucky | 31.8 | 0.99 |
| 29-Sep | Boise State | 35.1 | @ New Mexico | 13.7 | 21.39 |
| 29-Sep | Clemson | 37.2 | @ Boston College | 27.3 | 9.89 |
| 29-Sep | @ Connecticut | 38.4 | Buffalo | 7.7 | 30.74 |
| 29-Sep | Duke | 36.3 | @ Wake Forest | 26.6 | 9.68 |
| 29-Sep | @ East Carolina | 28.1 | Texas-El Paso | 24.2 | 3.90 |
| 29-Sep | Florida Int'l | 34.8 | @ La-Lafayette | 33.4 | 1.36 |
| 29-Sep | Florida State | 48.0 | @ South Florida | 18.7 | 29.25 |
| 29-Sep | @ Fresno State | 42.4 | San Diego State | 26.8 | 15.60 |
| 29-Sep | @ Georgia | 45.6 | Tennessee | 22.8 | 22.79 |
| 29-Sep | @ Georgia Tech | 47.6 | Middle Tennessee | 21.9 | 25.72 |
| 29-Sep | Houston | 48.8 | Rice | 38.0 | 10.81 |
| 29-Sep | @ Kent State | 34.0 | Ball State | 32.1 | 1.91 |
| 29-Sep | La-Monroe | 43.2 | @ Tulane | 20.7 | 22.54 |
| 29-Sep | Louisiana Tech | 43.6 | @ Virginia | 34.8 | 8.81 |
| 29-Sep | Louisville | 32.9 | @ Southern Miss | 22.9 | 10.03 |
| 29-Sep | @ Michigan State | 27.9 | Ohio State | 13.4 | 14.46 |
| 29-Sep | Minnesota | 21.6 | @ Iowa | 20.9 | 0.70 |
| 29-Sep | Missouri | 29.7 | @ Central Florida | 23.6 | 6.08 |
| 29-Sep | @ Nebraska | 39.3 | Wisconsin | 17.8 | 21.57 |
| 29-Sep | Nevada | 49.8 | @ Texas State | 28.7 | 21.05 |
| 29-Sep | @ North Carolina | 45.2 | Idaho | 12.6 | 32.63 |
| 29-Sep | North Carolina State | 33.8 | @ Miami-Florida | 24.5 | 9.29 |
| 29-Sep | North Texas | 29.8 | @ Florida Atlantic | 16.8 | 13.08 |
| 29-Sep | @ Northern Illinois | 38.6 | Central Michigan | 21.4 | 17.13 |
| 29-Sep | @ Northwestern | 38.6 | Indiana | 23.3 | 15.32 |
| 29-Sep | Ohio | 42.6 | @ Massachusetts | 12.2 | 30.37 |
| 29-Sep | @ Oklahoma State | 47.0 | Texas | 39.2 | 7.79 |
| 29-Sep | Oregon | 57.2 | Washington State | 15.0 | 42.23 |
| 29-Sep | Penn State | 21.8 | @ Illinois | 18.5 | 3.34 |
| 29-Sep | @ Purdue | 46.1 | Marshall | 32.1 | 13.97 |
| 29-Sep | San Jose State | 31.5 | @ Navy | 25.0 | 6.50 |
| 29-Sep | South Carolina | 35.1 | @ Kentucky | 14.4 | 20.68 |
| 29-Sep | T C U | 38.8 | @ S M U | 19.1 | 19.72 |
| 29-Sep | @ Texas A&M | 43.9 | Arkansas | 20.5 | 23.45 |
| 29-Sep | Texas Tech | 32.9 | @ Iowa State | 23.9 | 8.99 |
| 29-Sep | Troy | 26.0 | @ South Alabama | 23.4 | 2.59 |
| 29-Sep | Tulsa | 45.7 | @ U A B | 20.9 | 24.80 |
| 29-Sep | U C L A | 48.3 | @ Colorado | 20.4 | 27.83 |
| 29-Sep | U T S A | 30.5 | @ New Mexico State | 28.2 | 2.25 |
| 29-Sep | @ Utah State | 38.8 | U N L V | 15.8 | 23.00 |
| 29-Sep | Virginia Tech | 22.0 | Cincinnati | 19.1 | 2.82 |
| 29-Sep | @ West Virginia | 51.2 | Baylor | 42.1 | 9.04 |
| 29-Sep | @ Western Michigan | 37.8 | Toledo | 26.5 | 11.35 |
| FBS vs FCS | WEEK 5 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 29-Sep | @ Bowling Green | 38.5 | Rhode Island | 2.6 | 35.92 |
| 29-Sep | @ L S U | 42.9 | Towson | 6.0 | 36.90 |
| 29-Sep | Stony Brook | 37.9 | @ Army | 36.2 | 1.66 |
| FCS vs FCS | WEEK 5 | ||||
| DATE | FAVORITE | score | UNDERDOG | score | spread |
| 27-Sep | @ North Carolina A&T | 40.7 | Morgan State | 17.7 | 23.03 |
| 27-Sep | Sam Houston State | 56.4 | @ Texas Southern | 5.5 | 50.95 |
| 28-Sep | @ Harvard | 36.6 | Holy Cross | 14.2 | 22.36 |
| 29-Sep | @ Alabama A&M | 25.6 | Grambling | 14.8 | 10.85 |
| 29-Sep | Alabama State | 28.4 | @ Alcorn State | 14.4 | 14.00 |
| 29-Sep | @ Albany-NY | 28.2 | Monmouth | 21.0 | 7.22 |
| 29-Sep | @ Appalachian State | 35.8 | Coastal Carolina | 29.2 | 6.63 |
| 29-Sep | Bethune-Cookman | 33.6 | @ Hampton | 21.3 | 12.32 |
| 29-Sep | @ Butler | 23.9 | Dayton | 18.9 | 5.02 |
| 29-Sep | Central Arkansas | 36.9 | @ Stephen F Austin | 36.0 | 0.90 |
| 29-Sep | Colgate | 32.7 | @ Yale | 22.8 | 9.93 |
| 29-Sep | @ Columbia | 18.2 | Princeton | 14.9 | 3.30 |
| 29-Sep | Cornell | 26.4 | @ Bucknell | 21.4 | 5.02 |
| 29-Sep | Drake | 36.3 | @ Campbell | 15.5 | 20.85 |
| 29-Sep | @ Duquesne | 35.6 | St Francis-PA | 31.6 | 4.01 |
| 29-Sep | @ Eastern Illinois | 45.0 | Austin Peay | 27.6 | 17.42 |
| 29-Sep | Eastern Kentucky | 26.1 | @ Tennessee-Martin | 25.1 | 0.96 |
| 29-Sep | @ Eastern Wash | 34.6 | Montana | 23.8 | 10.80 |
| 29-Sep | Florida A&M | 31.1 | Southern U | 21.4 | 9.61 |
| 29-Sep | @ Furman | 40.9 | Western Carolina | 25.4 | 15.49 |
| 29-Sep | @ Georgetown | 26.4 | Brown | 20.8 | 5.62 |
| 29-Sep | @ Georgia Southern | 34.0 | Samford | 17.1 | 16.97 |
| 29-Sep | @ Howard | 42.9 | Savannah State | 19.8 | 23.15 |
| 29-Sep | @ Idaho State | 34.1 | Sacramento State | 33.3 | 0.71 |
| 29-Sep | Illinois State | 33.6 | @ South Dakota | 17.6 | 16.04 |
| 29-Sep | Indiana State | 23.0 | @ Southern Illinois | 21.5 | 1.44 |
| 29-Sep | @ Jackson State | 41.9 | Prairie View | 21.3 | 20.52 |
| 29-Sep | @ Jacksonville State | 45.2 | SE Missouri State | 25.4 | 19.77 |
| 29-Sep | Lafayette | 22.1 | @ Robert Morris | 11.9 | 10.17 |
| 29-Sep | @ Lehigh | 28.0 | Fordham | 19.6 | 8.42 |
| 29-Sep | @ Maine | 23.9 | Villanova | 18.7 | 5.25 |
| 29-Sep | Marist | 20.7 | @ Jacksonville | 17.8 | 2.88 |
| 29-Sep | @ McNeese State | 37.5 | Northwestern State | 20.9 | 16.67 |
| 29-Sep | Montana State | 39.6 | @ Southern Utah | 26.6 | 12.99 |
| 29-Sep | @ Murray State | 44.1 | Tennessee Tech | 34.9 | 9.21 |
| 29-Sep | @ New Hampshire | 35.2 | Delaware | 29.9 | 5.26 |
| 29-Sep | Norfolk State | 26.4 | @ South Carolina St | 23.0 | 3.48 |
| 29-Sep | @ North Dakota | 35.2 | Cal Poly | 30.7 | 4.46 |
| 29-Sep | North Dakota State | 30.2 | @ Northern Iowa | 19.6 | 10.60 |
| 29-Sep | @ Northern Arizona | 39.4 | Portland State | 30.0 | 9.45 |
| 29-Sep | Old Dominion | 45.1 | @ Richmond | 29.9 | 15.18 |
| 29-Sep | Pennsylvania | 20.7 | @ Dartmouth | 17.6 | 3.08 |
| 29-Sep | Presbyterian | 28.8 | @ Davidson | 22.5 | 6.29 |
| 29-Sep | @ Sacred Heart | 30.4 | Central Connecticut | 18.4 | 12.04 |
| 29-Sep | SE Louisiana | 23.4 | @ Lamar | 17.2 | 6.24 |
| 29-Sep | @ South Dakota State | 31.4 | Missouri State | 10.7 | 20.79 |
| 29-Sep | @ Tennessee State | 25.2 | Arkansas-Pine Bluff | 13.2 | 11.95 |
| 29-Sep | @ The Citadel | 30.2 | Chattanooga | 21.3 | 8.99 |
| 29-Sep | @ UC-Davis | 28.8 | Weber State | 23.8 | 4.95 |
| 29-Sep | @ Wagner | 30.0 | Bryant | 14.0 | 16.04 |
| 29-Sep | @ William & Mary | 28.3 | Georgia State | 13.8 | 14.51 |
| 29-Sep | Wofford | 37.0 | @ Elon | 22.8 | 14.23 |