LAMPSON LAB

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Training Opportunities

Brain and Brain Tumor Immunology

Post-doctoral.  Training is available in basic or translational projects.  Applicants with a variety of backgrounds are welcome.  Research areas:

·        Basic immune regulation in the CNS (T cell entry, triggering of effector function).

·        Site-specific immune control:  Underlying mechanisms & disease implications.

·        Implications for tumor therapy; autoimmunity; neuro-degeneration (studied in rodent models).

To apply, please briefly describe which area you would like to work in; your previous experience & how it could be relevant.  Apply by e-mail to:  lalampson@attbi.com

Pre-doctoral and undergraduate.  Students at all levels are able to participate in meaningful research.  Undergraduates must be able to commit two 4-hour time slots per week, during regular working hours.  To apply, please briefly describe previous laboratory experience outside of classes (if any); hours you can work; can you work during summer?; are you a work-study student?   Apply by e-mail to:  lalampson@attbi.com

 

Some former trainees at different levels

Wendy Armstrong, Harvard medical student.

Publication (in addition to thesis).  Armstrong, WS and Lampson, LA.  Direct cell-mediated responses in the  nervous system:  CTL vs. NK activity, and their dependence upon MHC expression and modulation.  In:  Immunology of the Nervous System, R.W. Keane and W.F. Hickey, eds., Oxford, 1997, pp. 493-547. 

Awards.  M.D. with honors in a special field; Carl Walter Fellowship (HMS).

Anthony Chen, Harvard undergraduate, senior thesis student.

Publication (in addition to thesis).  Lampson LA, Chen A, Vortmeyer AO, Sloan AE, Ghogawala Z, Kim L.  Enhanced T cell migration to sites of microscopic CNS disease:  Complementary treatments evaluated by 2- and 3-D image analysis.  Brain Pathol. 1994, 4: 125-34.

Award.  A.B. summa cum laude, 1994.

Tanya Dutta, Harvard undergraduate, senior thesis student.

Abstracts (in addition to thesis).  Dutta T, Spence A, Lampson LA.  MHC expression and IFN-mediated enhancement in the presence of growing brain tumor in situ.  Poster discussion, presented by T. Dutta, AACR Ann Mtg, 1998.

Lampson LA, Phillips LM, Dutta T.  T cell attack of brain stem glioma.  International Society of Neuroimmunology, Fifth International Congress, Montreal, August, 1998.

Dutta T, Lampson LA.  IFN-mediated MHC enhancement in the presence of growing brain tumor. International Society of Neuroimmunology, Fifth Int. Congress, Montreal, August, 1998.

Awards.  Harvard University, combined B.A. / M.A. magna cum laude.

Harvard College Research Program, student travel award, to present work at AACR (American Association of Cancer Research) annual meeting, New Orleans, March, 1998.

Ellen Lee, Harvard undergraduate.

Lee E, Lampson LA, Facilitating T cell attack of brain stem glioma.  American Association of Neuropathologists (AANP) annual meeting, 1999.

Lynnette Phillips McCluskey, Ph.D., post-doctoral fellow, Harvard Medical School.

Phillips LM, Simon P, Lampson LA.  Site-specific immune regulation in the brain:  differential modulation of MHC proteins in brainstem vs. hippocampus.  J. Comp. Neurol., 405: 322-333, 1999.

Phillips LM, Lampson LA.  Site-specific control of T cell traffic in the brain:  T cell entry to brain stem vs. hippocampus after local injection of IFN-g.  J. Neuroimmunol.  96: 212-221, 1999.

McCluskey L Phillips and Lampson LA.  Local immune regulation in the central nervous system by substance P vs. glutamate.  J. Neuroimmunol. 2001, 116: 136-146.

McCluskey L Phillips, Lampson LA. Local neurochemicals and site-specific immune regulation in the CNS. J Neuropathol Exp Neurol. 59: 177-187, 2000.

Co-organizer, Neurobiology 300:  The  neurobiology of immune regulation. 

Awards.  NIH/NINDS, post-doctoral support.

National MS Society (NMSS), post-doctoral support.

National Multiple Sclerosis Society (NMSS), Dale McFarlin Travel Award (1 of 2 awarded), to present work at International Neuroimmunology meeting, Montreal, August, 1998.

William J.D. Turner, undergraduate, University of Pennsylvania.

Turner, WJD, Chatten J, Lampson LA.  Human neuroblastoma cell growth in xenogeneic hosts:   Comparison of T cell-deficient and NK-deficient hosts, and subcutaneous or intravenous injection routes.  J. Neuro-Oncol., 1990, 8: 121-132.

Award.  Stellar Award for undergraduate research in neuroscience, University of Pennsylvania School of Medicine,

James P. Whelan, PhD student, University of Pennsylvania.

Publications (in addition to thesis). 

Lampson LA, Fisher CA, Whelan JP.  Striking paucity of HLA-A, B, C and b2-microglobulin on human neuroblastoma cell lines.  J. Immunol. 1983; 130: 2471-2478.

Whelan JP, Chatten J, Lampson LA.  HLA-A, B, C and b2-microglobulin expression in frozen and formaldehyde-fixed paraffin sections of neuroblastoma tumors. Cancer Res. 1985; 45: 5976-5983.

Whelan JP, Eriksson U, Lampson LA.  Expression of mouse b2-microglobulin in frozen and formaldehyde-fixed central nervous tissues:  Comparison of tissue behind the blood-brain barrier and tissue in a barrier-free region. J. Immunol. 1986; 137: 2561-2566.

Whelan JP, Wysocki CJ, Lampson LA.  Distribution of b2-microglobulin in olfactory epithelium: A proliferating neuroepithelium not protected by a blood-tissue barrier. J. Immunol. 1986; 137:  2567-2571.