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| New York | The Greatest city in the world |
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| Dave | Whoopi Goldberg |
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| 1st Guest | Jessica Lange |
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| 2nd Guest | Dave Chappelle |
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| Standup | Andy Vistola |
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| Music | Ben Harper |
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| Worldwide Pants |
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| New York | The Greatest city in the world |
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| Dave | Vince Vaughn |
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| 1st Guest | Rosie Perez |
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| 2nd Guest | Geri Halliwell |
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| Standup | Dwayne Kennedy |
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| Music | Paul Simon |
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| Worldwide Pants |
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| New York | The Greatest city in the world |
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| Dave | Elvis Costello |
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| 1st Guest | Kim Cattrell |
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| 2nd Guest | Eddie Izzard |
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| Standup | Mitch Hedberg |
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| Music | Elvis Costell |
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| Worldwide Pants |
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| New York | The Greatest city in the world |
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| Dave | Will Ferrell |
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| 1st Guest | Chris Rock |
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| 2nd Guest | Crispin Glover |
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| Standup | Jake Johannsen |
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| Music | American Hi-Fi |
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| Worldwide Pants |
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| New York | The Greatest city in the world |
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| Dave | Megan Mullally |
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| 1st Guest | Molly Shannon |
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| 2nd Guest | Isaac Mizrahi |
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| Standup | Bonnie McFarlane |
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| Music | Megan Mullally |
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| Worldwide Pants |
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| New York | The Greatest city in the world |
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| Dave | Brad Garrett |
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| 1st Guest | Cuba Gooding, Jr. |
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| 2nd Guest | Julie Bowen |
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| Standup | Reggie McFadden |
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| Music | Lyle Lovett - Straighten Up and Fly Right |
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| Worldwide Pants |
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| New York | The Greatest city in the world |
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| Dave | Tom Dreesen |
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| 1st Guest | Kiefer Sutherland |
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| 2nd Guest | Frank Gershin |
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| Standup | Suzanne Westenhoefer |
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| Music | The Music |
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| Worldwide Pants |
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| New York | The Greatest city in the world |
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| Dave | Bonnie Hunt |
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| 1st Guest | Carson Daley |
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| 2nd Guest | Eddie Griffin |
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| Cooking | Ron Beth-Israel |
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| Music | Fabolous |
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| Worldwide Pants |
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| New York | The Greatest city in the world |
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| Dave | Paul Schaffer |
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| 1st Guest | Bob Dole |
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| 2nd Guest | Connie Nielsen |
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| 3rd Guest | Jeff Foxworthy |
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| Music | Cat Power |
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| Worldwide Pants |
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| New York | The Greatest city in the world |
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| Dave | Bill Cosby |
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| 1st Guest | Andrew Firestone |
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| Music | Clark Tery |
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| 2nd Guest | Sofia Vergara |
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| Music | The DA |
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| Worldwide Pants |
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| New York | The Greatest city in the world |
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| Dave | Luke Wilson |
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| 1st Guest | Kelly Preston |
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| 2nd Guest | Taye Diggs |
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| 3rd Guest | Hilary Burton |
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| Music | Seether |
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| Worldwide Pants |
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| New York | The Greatest city in the world |
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| Dave | Recently on the cover of prescription pain killer magazine |
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| PostMonologue | It Hurt So Bad That... |
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| 2nd Bit | Guest Host video montage |
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| Top Ten | Good Things About Having the Shingles |
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| 1st Guest | Billy Crystal |
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| 2nd Guest | Michael Barimo |
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| Other | Tribute to George Miller |
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| Audience Shot | Late Show Office Pool |
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| Cute pants |
