Sections This bibilography is arranged by topic, with links to other web sites at the end. General Biology Golden Rice Alcohol Dehydrogenases Food Toxins Seed Saving Molecular Structures and Rendering Popular Books on Modern Biology Links to other web sites General Biology Nearly all of the information presented in Life's Big Instruction Book is well established, and can be found in standard biology text books. We consulted these books in preparing Life's Big Instruction Book: Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts K., Watson, J. D.; Molecular Biology of the Cell Third Edition; Garland Publishing; 1994 Stryer L., Biochemistry Third Edition; W. H. Freeman and Co; 1988 Watson, J. D., Hopkins, N., Roberts J., Steiz J., Weiner A.; Molecular Biology of the Gene Fourth Edition; Benjamin/Cummings Publishing Company; 1987 Hartl, D., Freifelder, D., Snyder, L.; Basic Genetics; Jones and Bartlett Publishers; 1987 Howe, C.; Gene Cloning and Manipulation; Cambridge University Press; 1995 Golden Rice Readers interested in the details of a genetic engineering project should look at the scientific paper describing Golden Rice. The paper is intended for a technical audience, but with the information from Life's Big Instruction Book, you should be able to follow along. Ye, X., Al-Babli, S., Klöti, A., Zhang, J., Lucca, P., Beyer, P., Potrykus I.; Engineering the Provitamin A (B-Carotene) Biosynthetic Pathway into (Carotenoid-Free) Rice Endosperm; Science 287, pp 303-305. Alcohol Dehydrogenases We consulted a few papers published in the scientific literature for detailed information on alcohol dehydrogenases. Yoshida, A.; Isozymes of Human Alcohol Dehydrogenase and Aldehyde Dehydrogenase; Isozymes: Structure, Function, and Use in Biology and Medicine, pp 327-340; 1990 Holmes, R. S; Alcohol Dehydrogenases: A Family of Isozymes with Differential Functions; Alcohol and Alcoholism, Supplement 2, pp 129-132; 1994 Ikuta, T., Szeto, S, Yoshida A.;Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence; PNAS 83, pp 634-638; 1986 Jörnvall, H., Höög J., Bahr-Lindström H., Vallee B. L.; Mammalian alcohol dehydrogenases of separate classes: Intermediates between different enzymes and intraclass isozymes; PNAS 84, pp 2580-2584; 1987 Food Toxins The FAQ mentions the presence of naturally-occurring toxins in food. These papers provide more information on that subject. The first two are a good introduction to the subject, even though they contain a lot of long technical terms. Don't worry about the terms; the discussions are the good part. Ames, B. N., Gold, L. S.; Dietary pesticides (99.99% all natural); PNAS 87, pp 7777-7781. Ames, B. N., Profet, M., Gold, L. S.; Nature's chemicals and synthetic chemicals: comparative toxicology; PNAS 87, pp 7782-7786. Franck-Oberaspach S. L., Keller B.; Consequences of classical and biotechnological resistance breeding for food toxicology and allergencity; Plant Breeding 116, pp 1-17; 1997. Pusztai, A.; The Role in Food Poisoning of Toxins and Allergens from Higher Plants; Dev. Food Microbiology 2, pp 179-194; 1986. Hanley, A. B., MacDonald, S. J.; Natural Plant Toxins -- Benefits and Risks; Environmental Topics 7, pp 291-315; 1998. Colegate, S. M., Edgar, J. A., Stegelmeier, B. L.; Plant-Associated Toxins in the Human Food Supply; Environmental Topics 7, pp 317-344; 1998. Seed Saving The Introduction to Agribusiness discusses the difficulties of saving seed for replanting. These books go into more detail on that subject: McDonald, M. B., Copeland, L.; Seed Production: Principles and Practices, chapters 6 - 8; Chapman & Hall; 1997. Jugenheimer, R. W.; Corn: Improvement, Seed Production, and Uses, Part V: Seed Production, Processing, and Distribution; Wiley; 1976. Molecular Structures and Rendering All of the pictures of proteins were made by Raster3D, using atomic coordinates from the Protein Data Bank. Their citations are: Raster3D Merritt, Ethan A and Bacon, David J.; Raster3D - photorealistic molecular graphics; Methods in Enzymology 277, pp505-524; 1997. http://www.bmsc.washington.edu/raster3d/raster3d.html The Protein Data Bank H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, P.E. Bourne; The Protein Data Bank; Nucleic Acids Research, 28 pp. 235-242; 2000 http://www.rcsb.org/pdb/ Coordinates Lac repressor complex PDB ID: 1EFA C. E. Bell, M. Lewis; A Closer View of the Conformation of the Lac Repressor Bound to the Operator; Nature Structural Biology 7; 2000 DNA-histone complex PDB ID: 1AOI K. Luger, A. W. Mader, R. K. Richmond, D. F. Sargent, T. J. Richmond; Crystal Structure of the Nucleosome Core Particle at 2.8A Resolution; Nature 389; 1997 Alcohol dehydrogenase 1 beta-1 PDB ID: 1HDX T. D. Hurley, L. M. Amzel; The Structure of Human Beta-1 Alcohol Dehydrogenase: Catalytic Effects of Non-Active-Site Substitutions; PNAS 88; 1991 Alcohol dehydrogenase sigma PDB ID: 1AGN P. Xie, S. H. Parsons, D. C. Speckhard, W. F. Borson, T. D. Hurley; X-ray Structure of Human Class IV Sigma Alcohol Dehydrogenase: Structural Basis for Substrate; to be published Alcohol dehydrogenase 1 beta-3 PDB ID: 1HTB G. J. Davis, W. F. Borson, C. L. Stone, K. Owusu-Deyki, T. D. Hurley; X-ray Structure of Human Beta-3 Alcohol Dehydrogenase: Electrostatic Contributions To Coenzyme Binding; to be published Aldehyde dehydrogenase PDB ID: 1A4Z C. G. Steinmetz, P. Xie, H. Weiner, T. D. Hurley; Structure of Mitochondrial Aldehyde Dehydrogenase: The Genetic Component of Ethanol Aversion; Structure (London) 5 1997 Books There are a number of good popular books that describe various topics presented in Life's Big Instruction Book in greater detail: popular books coming soon Links These other web sites also talk about biology: Biology Discussion and Education The Talk.Origins Archive is the archives for the newsgroup talk.origins, where people discuss evolution. The site includes a number of FAQs about evolution and biology in general. Biochemistry in 3D has interactive structures of proteins and tutorials about proteins. The Dolan DNA Learning Center has an abundance of information on genes and genetics. Human Genome Project Primers has introductions to the Human Genome Project and modern genetics. The Evolution Education Site Ring is a group of sites about evolution. Life's Big Instruction Book is a member of this web ring. Pro-biotechnology sites Monsanto's site is just a single page with a few links. Monsanto also sponsors the Biotech Knowledge Center which has a little more detail. DuPont/Pioneer Hi-Bred's site is very slick, but not very informative. Anti-biotechnology sites Greenpeace has a statement of their objection to genetic engineering, along with some justifications. Less slick than their usual marketing. Is there a site you like that isn't listed? Look at the suggestion page for how to tell us about it.

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