Pathway databases and websites

Alliance for Cellular Signaling (AfCS) – Nature Gateway

Nature magazine

Electronic journal. Sounds like a pathway site, but isn’t. 

Apoptosis Special Interest Site

Roche Diagnostics

Vendor website with detailed diagram of apoptosis pathway linked to products.

BioCarta

BioCarta

Vendor website of 285 annotated pathway diagrams linked to products.

Biological Biochemical Image Database (BBID)

Kevin Becker, National Institute on Aging, NIH

Collection of pathway diagrams from published papers.

Boehringer Mannheim - Biochemical Pathways

ExPASy, Swiss Institute of Bioinformatics

Online version of famous wall chart.

CellML Examples & Models

CellML.org (Physiome Sciences, Inc.)

Repository of ~125 models expressed in CellML mathematical formalism.

BioCyc (includes EcoCyc)

Peter Karp, SRI

Major database of E. Coli pathways. Umbrella BioCyc database has 477 pathways from several (mostly bacterial) species.

IUBMB-Nicholson Minimaps

Donald Nicholson, The University, Leeds, England

Online supplement to textbook with 26 diagrams of metabolic pathways.

Kyoto Encyclopedia of Genes and Genomes (KEGG)

Kyoto University Bioinformatics Center

Premier pathway database with more than 10,000 pathways.

Mammalian MAPK Signaling Pathways

James Woodgett, Princess Margaret Hospital, Toronto

Laboratory website with annotated diagram and text description of MAPK cascade.

SBML Model Repository

Maria Schilstra, University of Hertfordshire

Repository of 18 models expressed in SBML mathematical formalism.

Science Signal Transduction Knowledge Environment (STKE)

Science magazine

Electronic journal with 48 pathway diagrams, 14 of which are described in text perspectives.

Protein interaction databases

Biomolecular Interaction Network Database (BIND)

Chris Hogue, University of Toronto

Biomolecular Relations in Information Transmission and Expression (BRITE)

Kyoto University Bioinformatics Center

Database of Interacting Proteins (DIP)

David Eisenberg, University of California at Los Angeles

Molecular INTeraction database (MINT)

 

Gianni Cesareni, University of Rome

Human Protein Reference Database (HPRD)

Akhilesh Pandey, Johns Hopkins University

Categorized list of papers on analysis of protein interaction data

Standards and Interest Groups

BioPathways Consortium

 

Organizes conferences.

BioPAX : Biological Pathways Exchange

 

Focus on knowledge representation.

CellML

Co-development by Physiome and the Bioengineering Institute, University of Auckland

Mathematically oriented with focus on simulation and modeling.

Systems Biology Markup Language (SBML)

Associated with Systems Biology Workbench (SBW), ERATO Kitano Systems Biology Project

Mathematically oriented with focus on simulation and modeling.

Companies with simulation and modeling software             

Cellnomica

Entelos

Gene Network Sciences

Genomatica

Kenna Technologies

Physiome Science

Companies with pathway drawing software                         

BioCarta (free Freehand templates)

Stratagene (partnership with Iobion)