Which of the following statements is FALSE:

A.   

Large dosage adjustments are generally needed in patients receiving phenytoin due to its heavy first pass effect and rapid renal clearance.

B.   

Hepatotoxicity and blood dyscrasias are two serious side effects associated with valproic acid therapy.

C.   

Advantages of gabapentin include its broad therapeutic index, minimal CNS effects, and its absence of significant drug interactions.

D.   

In clinical studies, oxcarbazepine is as effective as phenytoin, valproic acid, and carbamazepine, and was better tolerated with fewer side effects.

E.   

Caution must be exercised when interpreting phenytoin levels in patients with hypoalbuminemia.

(Click the correct answer)