Those classified as overweight have 4 percent less brain tissue and their brains appear to have aged prematurely by 8 years. The results, based on brain scans of 94 people in their 70s, represent "severe brain degeneration," said Paul Thompson, senior author of the study and a UCLA professor of neurology.
When the volunteers were retested five years later the medics found those with the lowest levels of vitamin B12 were also the most likely to have brain shrinkage. It confirms earlier research showing a link between brain atrophy and low levels of B12. ... Researchers found that the hippocampus-the part of the brain that stores memories - was 10 percent smaller in beer drinkers than those who stuck to wine.
The researchers, led by Associate Professor Ana Maria Cuervo, blocked the ageing process in mice livers by stopping the build-up of harmful proteins inside the organ's cells. As people age their cells become less efficient at getting rid of damaged protein resulting in a build-up of toxic material that is especially pronounced in Alzheimer's, Parkinson's and other neurodegenerative disorders. The researchers say the findings suggest that therapies for boosting protein clearance might help stave off some of the declines in function that accompanies old age.
Today, in the journal PLoS ONE, researchers report that even low doses of resveratrol in the diet of middle-aged mice has a widespread influence on the genetic levers of ageing, and may confer special protection on the heart.
The results of the research do not rule out the possibility that other genetic mutations could positively influence longevity. However, researchers do point out the fact that the excellent health of this family, and of the 113-year-old man in particular, is probably due to a Mediterranean diet, the temperate climate of the island, a lack of stress and regular physical activity. The article underlines the fact that until the age of 102, the man cycled every day and looked after the family orchard.
“What we noticed right away was that the long-lived strains always had mutations in the large ribosomal subunit and never in the small subunit,” said the study's lead author, Kristan Steffen, a graduate student in the UW Department of Biochemistry.
Millions of dieters would give their right arm to be afflicted by the illness that is plaguing John Perry. He cannot put on weight because of a condition called lipodystrophy that makes his body rapidly burn fat.
Men who took folic acid supplements and who ate folate-rich foods such as leafy greens had fewer abnormal sperm, the team at the University of California, Berkeley said.
Sugar can react with proteins in the body in a process called protein glycation. Oxidants can further chemically modify these glycated proteins, producing “advanced glycation endproducts” or AGE. The accumulation of these modified proteins has been implic
