The Division of Reproductive and Developmental Biology Department of Pediatrics at Vanderbilt University Medical Center VU Help Search Vanderbilt Medical Center Jeff Reese, MD Sanjoy K. Das, Ph.D Bibhash C. Paria, Ph.D S. K. Dey, Ph.D
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GROWTH FACTORS AND CYTOKINES SIGNALING
There are numerous families of growth factors and their receptors that contribute to various stages of reproduction. A small number of these molecules are important for embryo implantation. The following papers from our division focus on the roles of growth factors, cytokines and related molecules in reproduction.

Wang X, Wang H, Matsumoto H, Roy SK, Das SK, Paria BC
Dual source and target of heparin-binding EGF-like growth factor during the onset of implantation in the hamster.
Development. 2002 Sep;129(17):4125-34.


Leach RE, Romero R, Kim YM, Chaiworapongsa T, Kilburn B, Das SK, Dey SK, Johnson A, Qureshi F, Jacques S, Armant DR.
Pre-eclampsia and expression of heparin-binding EGF-like growth factor.
Lancet. 2002 Oct 19;360(9341):1215-9.


Matsumoto H, Zhao X, Das SK, Hogan BL, Dey SK.
Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus.
Dev Biol. 2002 May 15;245(2):280-90.


Leach RE, Khalifa R, Armant DR, Brudney A, Das SK, Dey SK, Fazleabas AT.
Heparin-binding EGF-like growth factor modulation by antiprogestin and CG in the baboon (Papio anubis).
J Clin Endocrinol Metab. 2001 Sep;86(9):4520-8.


Julian J, Das SK, Dey SK, Baraniak D, Ta VT, Carson DD.
Expression of heparin/heparan sulfate interacting protein/ribosomal protein l29 during the estrous cycle and early pregnancy in the mouse.
Biol Reprod. 2001 Apr;64(4):1165-75.


Paria BC, Ma W, Tan J, Raja S, Das SK, Dey SK, Hogan BL.
Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors.
Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1047-52.


Song H, Lim H, Das SK, Paria BC, Dey SK.
Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient
mice.
Mol Endocrinol. 2000 Aug;14(8):1147-61.


Passavant C, Zhao X, Das SK, Dey SK, Mead RA.
Changes in uterine expression of leukemia inhibitory factor receptor gene during pregnancy and its up-regulation by prolactin in the western spotted
skunk.
Biol Reprod. 2000 Jul;63(1):301-7.


Reese J, Binart N, Brown N, Ma WG, Paria BC, Das SK, Kelly PA, Dey SK.
Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR.
Endocrinology. 2000 May;141(5):1872-81.


Halder JB, Zhao X, Soker S, Paria BC, Klagsbrun M, Das SK, Dey SK. Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation.
Genesis. 2000 Mar;26(3):213-24.


Leach RE, Khalifa R, Ramirez ND, Das SK, Wang J, Dey SK, Romero R, Armant DR.
Multiple roles for heparin-binding epidermal growth factor-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentation.
J Clin Endocrinol Metab. 1999 Sep;84(9):3355-63.


Paria BC, Elenius K, Klagsbrun M, Dey SK.
Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation.
Development. 1999 May;126(9):1997-2005.


Hirzel DJ, Wang J, Das SK, Dey SK, Mead RA.
Changes in uterine expression of leukemia inhibitory factor during pregnancy in the Western spotted skunk.
Biol Reprod. 1999 Feb;60(2):484-92.


Leach RE, Khalifa R, Ramirez ND, Das SK, Wang, J, Dey SK , Romero R and Armant DR.
Multiple roles of heparin-binding EGF-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentation.
J Clin Endo Metab 84:3355-3363, 1999.
 

Paria BC, Klaus E, Klagsbrun M and Dey SK.
Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: A possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation.
Development 126:1997-2005, 1999.
 

Das SK, Das N, Wang J, Schryver B, Plowman GD and Dey SK.
Expression of Betacellulin and Epiregulin Genes in the Mouse Uterus Temporally by the Blastocyst Solely at the Site of its Apposition is Coincident with the "Window" of Implantation.
Dev Biol 190:178-190, 1997.
 

Das SK, Lim H, Wang J, Paria BC, BazDresch M and Dey SK.
Inappropriate expression of human TGF-a in the uterus of transgenic mouse causes downregulation of TGF-b receptors and delays the blastocyst attachment reaction.
J Mol Endo 18:243-257, 1997.
 

Smith SE, French M, Julien J, Paria BC, Dey SK and Carson DD.
Expression of heparan sulfate proteoglycan (perlecan) in the mouse blastocyst is regulated during normal and delayed implantation.
Dev Biol 184:38-47, 1997.
 

Elenius K, Allison G, Das SK, Paria BC, Dey SK and Klagsbrun M.
Interaction of heparin-binding EGF-like growth factor with multiple receptors. Proceedings of the Earnst Schering Research Foundation Workshop Series, (eds. R. Lichtner & R. N. Harkins), Springer-Verlag,
 Berlin, Germany, pp. 46-64, 1997.


Lim H, Dey SK and Das SK.
Differential expression of the erbB2 gene the uterus: Potential mediator of signaling by epidermal growth factor (EGF)-like growth factors.
Endocrinology 138:1328-1337, 1997.
 

Liang L, Kover K, Dey SK and Andrews GK.
Regulation of interleukin-6 and interleukin- 1a gene expression in the mouse deciduum.
J Reprod Immunol 30:29-52, 1996.
 

Tong BJ, Das SK, Threadgill D, Magnuson T and Dey SK.
Differential expression of the full-length and truncated forms of the epidermal growth factor receptor in the preimplantation mouse uterus and blastocyst.
Endocrinology 137:1492-1496, 1996.
 

Raab G, Kover K, Paria BC, Dey SK, Ezzell R and Klagsbrun M.
Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor.
Development 122:637-645, 1996.
 

Das SK, Chakraborty I, Paria BC, Wang X-N, Plowman G and Dey SK.
Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus.
Molecular Endocrinology 9:691-705, 1995.
 

Kover K, Liang L, Andrews GK and Dey SK.
Differential expression and regulation of cytokine genes in the mouse uterus.
Endocrinology 51:597-606, 1995.
 

Kover K, Liang L, Andrews GK and Dey SK.
Differential expression and regulation of cytokine genes in the mouse uterus.
Endocrinology 51:597-606, 1995.
 

Wang X-N, Das SK, Damm D, Klagsbrun M, Abraham JA and Dey SK.
Differential regulation of heparin-binding EGF-like growth factor in the adult ovariectomized mouse uterus by progesterone and estrogen.
Endocrinology 135:1264-1271, 1994.
 

Paria BC, Das SK, Mead RA and Dey SK.
Expression of epidermal growth factor receptor in the preimplantation uterus and blastocyst of the western spotted skunk.
Biol Reprod 51:205-213, 1994.


Das SK, Wang X-N, Paria BC, Damm D, Abraham JA, Klagsbrun M, Andrews GK and Dey SK.
Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: A possible ligand for interaction with blastocyst EGF-receptor in implantation.
Development 120:1071-1083, 1994.
 

 Das SK, Tsukamura H, Paria BC, Andrews GK and Dey SK.
 Differential expression of epidermal growth factor receptor (EGF-R) gene and regulation of EGF-R bioactivity by progesterone and estrogen in the adult mouse uterus.
Endocrinology 134:971-981, 1994.
 

Paria BC, Das SK, Huet-Hudson YM and Dey SK.
Distribution of transforming growth factor-a precursors in the mouse uterus during the periimplantation period and after steroid hormone treatments.
Biol Reprod 50:481-491, 1994.
 

Paria BC, Das SK, Andrews GK and Dey SK.
Expression of epidermal growth factor receptor gene is regulated in the blastocyst during delayed implantation in the mouse.
Proc Natl Acad Sci USA 90:55-59, 1993.
 

Dey SK, Paria BC, Das SK and Andrews GK (1993)
Trophoblast-uterine interactions in implantation: Role of transforming growth factor-a/epidermal growth factor receptor signalling. In: Trophoblast Cells: Pathways for Maternal-Embryonic Communication (Eds. Soares MJ, Handwerger S & Talamantes F), Serono Symposium, 
Springer-Verlag, New York, pp.71-91, 1993. 
 

Dey SK, Das SK, Paria BC, Flanders KC and Andrews GK (1993)
Expression and binding of transforming growth factor-as in the mouse embryo and uterus during the periimplantation period. In: In Vitro Fertilization and Embryo Transfer in Primates
(Eds. Wolf DP, Stouffer RL & Brenner RM), Serono Symposium, Springer-Verlag, New York, pp.195-219, 1993. 


Zhang Y, Paria BC, Dey SK and Davis DL.
Characterization of the epidermal growth factor receptor in preimplantation pig conceptuses.
Dev. Biol. 151: 617-621, 1992.
 

Das, S. K., Flanders, K. C., Andrews, G. K. and Dey, S. K.
Expression of transforming growth factor-a isoform (a2 and a3) in the mouse uterus: Analysis of the preimplantation period and effects of ovarian steroids.
Endocrinology 130: 3459-3466, 1992
 

Paria, B. C., Jones, K. L., Flanders, K. C. and Dey, S. K.
Localization and binding of transforming growth factor-a isoforms in mouse preimplantation embryos and in delayed and activated blastocysts.
Dev. Biol. 151: 91-104, 1992.
 

Kapur, S., Tamada, H. Dey, S. K. and Andrews, G. K.
Expression of insulin-like growth factor-I and its receptor in the peri-implantation mouse uterus, and cell-specific regulation of insulin-like growth factor-I gene expression by estradiol and progesterone.
Biol. Reprod. 46:208-219, 1992.
 

McMaster, M.T., Teng, C.T., Dey, S.K., and Andrews, G.K.
Lactoferrin in the mouse uterus: analyses of the preimplantation period and regulation by ovarian steroids.
Mol. Endocrinol. 6:101-111, 1991.
 

Paria, B.C., Tsukamura, H., and Dey, S.K.
Epidermal growth factor-specific protein tyrosine phosphorylation in preimplantation embryo development.
Biol. Reprod. 45: 711-718, 1991.
 

Paria, B.C., Das, S.K., Gupta, A., and Dey, S.K.
Reversal of Indomethacin Induced Inhibition of Implantation by epidermal growth factor.
Prostaglandins 42: 191-199, 1991.
 

Tamada, H., Das, S.K., Andrews, G.K., and Dey, S.K. Cell
Type-Specific Expression of Transforming Growth Factor-a in the Mouse Uterus During the Periimplantation Period.
Biol. Reprod. 45: 365-372, 1991.


 Andrews, G.K., De, S.K., McMaster, M.T. and Dey, S.K.
Expression of metallothionein genes in preimplantation embryos, decidua and placentae.
In: Cellular Signals Controlling Uterine Functions (Ed. Lavia, L.A.),
Plenum Publishing Co. pp. 63-80, 1991.


Dey, S.K., Paria, B.C. and Andrews, G.K. Uterine EGF
ligand-receptor circuitry and its role in embryo-uterine interactions during implantation in the mouse. In: Uterine and embryonic factors in early factors (Eds. Strauss, J.F. & Lyttle, C.R.),
Plenum Publishing Corporation, New York, pp.51-69, 1991.


Huet-Hudson, Y.M., G.K. Andrews and S.K. Dey.
Epidermal growth factor and pregnancy in the mouse. J. Cell Biochem.
In: Early Embryo Development and Paracrine Relationships (UCLA Symposium, Eds. Heyner, S. & Wiley, L.M.), Wiley-Liss, New York, Vol. 117, pp.125-136, 1990.
 

Tamada, H., M.T. McMaster, K.C. Flanders, G.K. Andrews and S.K. Dey.
Cell type-specific expression of TGF-a1 in the mouse uterus during the periimplantation period.
Mol. Endocrinol. 4:965-972,1990.
 

Huet-Hudson, Y.M., C. Chakraborty, S.K. Dey, Y. Suzuki, G.K. Andrews and S.K. Dey.
Estrogen regulates synthesis of EGF in mouse uterine epithelial cells.
Mol. Endocrinol. 4:5l0- 523, 1990.


Chakraborty, C., O.W. Tawfik, and S.K. Dey.
Epidermal growth factor binding in the rat uterus during the peri-implantation period. Biochem.
Biophys. Res. Comm. 153:564-569, 1988.

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