The Division of Reproductive and Developmental Biology Department of Pediatrics at Vanderbilt University Medical Center VU Help Search Vanderbilt Medical Center Jeff Reese, MD Sanjoy K. Das, Ph.D Bibhash C. Paria, Ph.D S. K. Dey, Ph.D
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ENDOCANNABINOID SIGNALING
Endocannabinoids are arachidoneate derivatives in the cell which share similar functions to the cannabis family of psychoactive compounds. Cannabinoids and their receptors have unique roles in the embryo and uterus during implantation. The following papers illustrate our recent studies on endocannabinoid signaling in reproduction.

Paria BC, Wang H, Dey SK.
Endocannabinoid signaling in synchronizing embryo development and uterine receptivity for implantation.
Chem Phys Lipids. 2002 Dec;121(1-2):201-10.


Hough LB, Nalwalk JW, Stadel R, Timmerman H, Leurs R, Paria BC, Wang X, Dey SK.
Inhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptors.
J Pharmacol Exp Ther. 2002 Oct;303(1):314-22.


Paria BC, Song H, Wang X, Schmid PC, Krebsbach RJ, Schmid HH, Bonner TI, Zimmer A, Dey SK.
Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation.
J Biol Chem. 2001 Jun 8;276(23):20523-8.


Paria BC, Dey SK.
Ligand-receptor signaling with endocannabinoids in preimplantation embryo development and implantation.
Chem Phys Lipids. 2000 Nov;108(1-2):211-20. Review.


Paria BC, Zhao X, Wang J, Das SK, Dey SK.
Fatty-acid amide hydrolase is expressed in the mouse uterus and embryo during the periimplantation period.
Biol Reprod. 1999 May;60(5):1151-7.


Wang J, Paria BC, Dey SK, Armant DR.
Stage-specific excitation of cannabinoid receptor exhibits differential effects on mouse embryonic development.
Biol Reprod. 1999 Apr;60(4):839-44.


Paria BC, Zhao X, Wang J, Das SK and Dey SK.
Fatty-acid amide hydrolase is expressed in the mouse uterus and embryo during the periimplantation period.
Biol Reprod (In press).
 

Wang J, Paria BC, Dey SK and Armant DR.
Stage-specific excitation of cannabinoid receptor exhibits differential effects of mouse embryonic development.
Biol Reprod 60:839-844, 1999.
 

Deutsch DG, Goligorski MS, Schmid PC, Krebsbach RJ, Schmid HHO, Das SK, Dey SK, Arreaza, Thorup C, Stefano G and Moore LC.
Production and Phsiological actions of anandamide in the vasculature of the rat kidney.
J Clin Invest 100:1538-1546, 1997.
 

Schmid PC, Paria BC, Krebsbach RJ, Schmid HHO and Dey SK.
Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation.
Proc Natl Acad Sci USA 94:4188-4192, 1997.
 

Yang Z-M, Paria BC and Dey SK.
Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development.
Biol Reprod 55:756-761, 1996.
 

Paria BC, Deutsch DD and Dey SK.
The uterus is a potential site for anandamide synthesis and hydrolysis: Differential profiles of
anandamide synthase and hydrolase activities in the mouse uterus during the periimplantation period.
Mol Reprod Dev 45:183-192, 1996.
 

Paria BC, Das SK and Dey SK.
The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling.
Proc Natl Acad Sci USA 92:9460-9464, 1995.
 

Das SK, Paria BC, Chakraborty I and Dey SK.
Cannabinoid ligand-receptor signaling in the mouse uterus.
Proc Natl Acad Sci USA 92:4332-4336, 1995.
 

Paria BC, Wang X-N and Dey SK.
Effects of chronic treatment with D-9- tetrahydrocannabinol on uterine growth in the mouse.
Life Sci 55:729-734, 1994.
 

Das SK, Paria BC, Andrews GK and Dey SK.
Effects of 9-ene-tetrahydrocannabinol on expression of _-type transforming growth factors, insulin-like growth factor-I and c-myc genes in the mouse uterus.
J. Steroid Biochem and Mol Biol. 45:459-465, 1993.
 

Paria BC, Kapur S and Dey SK.
Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse.
J. Steroid Biochem. Mol. Biol. 42: 713-719, 1992.

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