The Division of Reproductive and Developmental Biology Department of Pediatrics at Vanderbilt University Medical Center VU Help Search Vanderbilt Medical Center Jeff Reese, MD Sanjoy K. Das, Ph.D Bibhash C. Paria, Ph.D S. K. Dey, Ph.D
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PREIMPLANTATION EMBRYO DEVELOPMENT AND IMPLANTATION
Synchronized development of the embryo to the active blastocyst stage and molecular cross-talk between the blastocyst and the uterus are essential to the process of implantation. These papers detail our research on embryo-uterine interactions.

Ma WG, Song H, Das SK, Paria BC, Dey SK.
Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation.
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2963-8.


Daikoku T, Matsumoto H, Gupta RA, Das SK, Gassmann M, DuBois RN, Dey SK.
Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner. Evidence for differential function of HIFs during early pregnancy.
J Biol Chem. 2003 Feb 28;278(9):7683-91.


Lim H, Dey SK.
A novel pathway of prostacyclin signaling-hanging out with nuclear receptors.
Endocrinology. 2002 Sep;143(9):3207-10. Review.


Paria BC, Reese J, Das SK, Dey SK.
Deciphering the cross-talk of implantation: advances and challenges.
Science. 2002 Jun 21;296(5576):2185-8. Review.


Lim H, Song H, Paria BC, Reese J, Das SK, Dey SK.
Molecules in blastocyst implantation: uterine and embryonic perspectives.
Vitam Horm. 2002;64:43-76. Review.


Reese J, Das SK, Paria BC, Lim H, Song H, Matsumoto H, Knudtson KL, DuBois RN, Dey SK.
Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation.
J Biol Chem. 2001 Nov 23;276(47):44137-45.


Carson DD, Bagchi I, Dey SK, Enders AC, Fazleabas AT, Lessey BA, Yoshinaga K.
Embryo implantation.
Dev Biol. 2000 Jul 15;223(2):217-37. Review.


Paria BC, Lim H, Das SK, Reese J, Dey SK.
Molecular signaling in uterine receptivity for implantation.
Semin Cell Dev Biol. 2000 Apr;11(2):67-76. Review.


Zhao X, Ma W, Das SK, Dey SK, Paria BC.
Blastocyst H(2) receptor is the target for uterine histamine in implantation in the mouse.
Development. 2000 Jun;127(12):2643-51.


Lim H, Ma L, Ma WG, Maas RL, Dey SK.
Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse.
Mol Endocrinol. 1999 Jun;13(6):1005-17.


Paria BC, Zhao X, Das SK, Dey SK, Yoshinaga K.
Zonula occludens-1 and E-cadherin are coordinately expressed in the mouse uterus with the initiation of implantation and decidualization.
Dev Biol. 1999 Apr 15;208(2):488-501.


Lim H, Ma L, Ma W-G, Mass RL and Dey SK.
Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and
decidualization in the mouse.
Mol Endo 13:1005-1017, 1999.
 

Das SK, Lim H, Paria BC and Dey SK.
Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy.
J Mol Endo 22:91-101, 1999.
 

Paria BC, Lim H, Wang X-N, Liehr J, Das SK and Dey SK.
Coordination of Differential effects of primary estrogen and catecholestrogen on two distinct targets mediates embryo implantation in the mouse.
Endocrinology 139:5235-5246, 1998.
 

Ma L, Benson GV, Lim H, Dey SK and Mass RL.
Abdominal B (AbdB) hoxa genes: Regulation in adult uterus by estrogen and progesterone and repression in Mullerian duct by the synthetic estrogen diethylstilbestrol (DES).
Dev Biol 197:141-154, 1998.
 

Das SK, Yano S, Wang J, Edwards DR, Nagase H and Dey SK.
Expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in the mouse uterus during the periimplantation period.
Dev Genetics 21:44-54, 1997.
 

Das N, Wang J and Dey SK.
Uterine preparation for implantation in the mouse is associated with coordinate expression of estrogen-responsive finger protein (Efp) and estrogen receptor.
Mol Reprod Dev 46:499-506, 1997.
 

Salamonsen LA, Jeziorska M, Newlands GFJ, Dey SK and Wooley DE.
Evidence against a significant role for mast cells in blastocyst implantation in the rat and mouse.
Reprod Fertil Dev 8:1157-1164, 1997.
 

Dalton T, Paria BC, Fernando LP, Huet-Hudson YM, Dey SK and Andrews GK.
Delineation of promoter function and protein-DNA interactions during activation of the chicken metallothionein promoter by oxidative stress.
Comparative Biochemistry and Physiology 116:75-86, 1997.
 

Benson GV, Lim H, Paria BC, Satokata I, Dey SK and Maas RL.
Mechanisms of female infertility in Hoxa-10 mutant mice: Uterine homeosis versus loss of maternal Hoxa-10 expression.
Development 122:2687-2696, 1996.
 

Stromstedt M, Keeney DS, Waterman MR, Paria BC, Conley AJ and Dey SK.
Preimplantation mouse blastocysts fail to express CYP genes required for estrogen biosynthesis.
Mol Reprod Dev 43:428-436, 1996.
 

Surveyor GA, Gendler SJ, Pemberton L, Das SK, Chakraborty I, Pimental RA, Wegner CC, Dey SK and Carson DD.
Expression and steroid hormonal control of Muc-1 in the mouse uterus.
Endocrinology 136:3639-3647, 1995.
 

McMaster MT, Dey SK and Andrews GK.
Association of monocytes and neutrophils with early events of blastocyst implantation in the mouse.
J. Reprod. Fert. 99:561-569, 1993.
 
Paria BC, Huet-Hudson YM and Dey SK.
Blastocyst1s state of activity determines the "window" of implantation in the receptive mouse uterus.
Proc Natl Acad Sci USA 90:10159-10162, 1993.
 
De SK, Paria BC, Dey SK and Andrews GK.
Stage-specific effects of cadmium on preimplantation embryo development and implantation in the mouse.
Toxicology 80:13-25, 1993.
 

Kogo H, Johnson DC, Dey SK and Takeo S.
A comparison of the effects of estradiol and 2- and 4-hydroxyestradiol on uterine ornithine decarboxylase activity in immature rats.
Japan J. Pharmacol 61: 65-67,1993.
 

Paria BC, Dey SK and Andrews GK.
Antisense C-myc effects on preimplantation mouse embryo development.
Proc. Natl. Acad. Sci. USA, 89: 10051-10055, 1992.
 

McMaster, M. T., Newton, R.C., Dey, S. K. and Andrews, G. K.
Activation and distribution of inflammatory cells in the mouse uterus during the periimplantation period.
J. Immunology 148:1697-1705, 1992.
 

Andrews, G.K., Huet-Hudson, Y.M., Paria, B.C., McMaster, M.T., De, S.K.and Dey, S.K.
Metallothionein gene expression and metal regulation during preimplantation mouse embryo development.
Dev. Biol. 145:13-27,1991
 

Johnson, D.C., Sen, M., Kogo, H. and Dey, S.K.
Initiation of embryo implantation and maintenance of early pregnancy in the rat by Chlordecone (Kepone).
Proc. Soc. Exp. Biol. Med. 195:44-50, 1991.
 

McMaster, M.T., Teng, C.T., Dey, S.K., and Andrews, G.K.
Lactoferrin in the mouse uterus: analyses of the preimplantation period and regulation by ovarian steroids.
Mol. Endocrinol. 6:101-111, 1991.
 

Chakraborty C, Davis DL and Dey SK.
O-methylation of catechol oestrogens by pig blastocysts and endometria during the peri-implantation period.
J. Endocrinol. 127:77-84, 1990.
 

De, S.K., Dey, S.K. and Andrews, G.K.
Cadmium teratogenicity and its relationship with metallothionein gene expression in midgestation mouse embryos.
Toxicology 64:89-104, 1990.
 

Paria, B.C. and S.K. Dey.
Preimplantation embryo development in vitro: Cooperative interactions among embryos role of growth factors.
Proc. Natl. Acad. Sci. USA. 87:4756- 4760, 1990.
 

Paria, B.C., C. Chakraborty and S.K. Dey.
Catechol estrogen formation in the mouse uterus and its role in implantation.
Mol. Cell. Endocrinol. 69:25-32, 1990.
 

Chakraborty, C., D.L. Davis and S.K. Dey.
Estradiol-15a-hydroxylation: A new avenue of estrogen metabolism in peri-implantation pig blastocysts.
J. Steroid Biochem. 35:209-218, 1990.
 

Chakraborty, C., Y.M. Huet-Hudson and S.K. Dey.
Catecholoestrogen synthesis and metabolism in the rabbit uterus during the periimplantation period.
J. Steroid Biochem. 35:39-46, 1990.
 

Huet, Y.M. and S.K. Dey.
Requirement for progesterone-priming and its long-term effect on implantation in the mouse.
Proc. Soc. Exptl. Biol. Med. 193:259-263, 1990.
 

Huet, Y.M. and S.K. Dey.
Differential effects of ovarian steroid and triphenylethylene compounds on macromolecular uptake and thymidine incorporation in the mouse uterus.
J. Steroid Biochem. 35:23-27, 1990.
 

De, S.K., M.T. McMaster, S.K. Dey and G.K. Andrews.
Cell-specific metallothionein gene expression in mouse decidua and placentae.
Development 107:611-621, 1989.
 

Huet, Y.M., G.K. Andrews and S.K. Dey.
Cell type-specific localization of c-myc protein in the mouse uterus: Modulation by steroid hormones and analysis of the periimplantation period.
Endocrinology 125:1683-1690, 1989.
 

Chakraborty, C., S.K. Dey and D.L. Davis.
Patterns and tissue distribution of Catechol estrogen forming activity by pig conceptuses during the peri-implantation period.
J. Anim. Sci. 67:991-998, 1989.
 

Johnson, D.C., H. Kogo, M. Sen and S.K. Dey.
Multiple estrogenic action of O,P1-DDT: Initiation and maintenance of pregnancy in the rat.
Toxicology 53:79-87, 1988.
 

Chakraborty, C., D.L. Davis, and S.K. Dey.
Characteristics of estrogen-2/4-hydroxylase in pig blastocysts: inhibition by steroidal and nonsteroidal agents.
J. Steroid Biochem. 31:231- 235, 1988.
 

Huet, Y.M. and S.K. Dey.
A paradoxical effect of an anti-estrogen, CI-628, on implantation in the mouse.
Proc. Soc. Exptl. Biol. Med. 189:61-65, 1988.
 

Long, S., S.K. Dey, and D.C Johnson.
2-fluoroestradiol does not cause uterine refractoriness but inhibits oestradiol-induced implantation in rats.
J. Reprod. Fert. 80:649-652, 1987.
 

Huet, Y.M. and S.K. Dey.
Role of early and late oestrogenic effects on implantation in the mouse.
J. Reprod. Fert. 81:453-458, 1987.
 

Dey, S.K. and D.C. Johnson.
Adrenal gland modulates oestrogen requirement for implantation in the rat.
J. Reprod. Fert. 79:655-657, 1987
 

Andrews, G.K., Y.M. Huet, L.D. Lehman, and S.K. Dey.
Metallothionein gene regulation in the preimplantation rabbit blastocyst.
Development 100:463-469, 1987.
 

Dey, S.K. and D.C. Johnson.
Embryonic signals of pregnancy.
N.Y. Acad. Sci. 476:49-62, 1986.
 

Dey, S.K., D.C. Johnson, P.L. Pakrasi and J.G. Lier.
Estrogens with reduced catechol forming capacity fail to induce implantation in the rat.
Proc. Soc. Exptl. Biol. Med. 181:215, 1986.
 

Mondschein, J., R.M. Hirsey, S.K. Dey., D.L. Davis and J. Weisz.
Catechol estrogen formation by pig blastocysts during the preimplantation period: Biochemical characterization of estrogen-4-hydroxylase and correlation with aromatase activity.
Endocrinology 117:2339, 1985.
 

Voogt, J.L., P.L. Pakrasi, D.C. Johnson and S.K. Dey. Evidence for
pituitary regulation of placental lactogen in the rat.
J. Endocrinol. 107:121, 1985.
 

Books and Chapters:

 
Paria BC, Das SK and Dey SK.
Embryo implantation requires estrogen-directed uterine preparation and catecholestrogen-mediated embryonic activation.
Advances in Pharmacology (eds. Goldstein DS, Eisenhofer G & McCarty R), Academic Press, New York, pp.840-843, 1998.
 

Das SK, Paria BC, Johnson DC and Dey SK.
Embryo-uterine interactions during implantation: Potential sites of interference by environmental
toxins.
In: Comprehensive Toxicology (eds. Sipes IG, McQueen CA & Gandolfi AJ), Pargamon Press, New York., vol.10, pp.317-328, 1997.
 

Dey, SK.
Implantation, In: Reproductive Endocrinology, Surgery and Technology (Eds. E. Y. Adashi, J. A. Rock and Z. Rosenwaks),
Lippincot-Raven Press, New York, New York, pp.421-434, 1995.
 

Andrews GK, McMaster MT, De SK, Paria BC and Dey SK.
Cell-specific expression and regulation of the mouse metallothionein-I and -II genes in the reproductive tract and preimplantation embryo.
In: Metallothionein II (Suzuki, KT, Imura N and Kimura M. eds.), Advances in Life Sciences Series, Birkhauser Verlag Basel/Switzerland, pp. 351-362, 1993.
 

Dey, S.K., and Paria, B.C.
Chemical Signals in Embryo-Maternal Dialogue: Role of Growth Factors.
In: Preimplantation Embryo Development (Ed. Bavister BD), Serono Symposium, Springer-Verlag,
New York, pp.264-275, 1993.
 

Huet, Y.M., G.K. Andrews and S.K. Dey.
Modulation of c-Myc protein in the mouse uterus during pregnancy and by steroid hormones.
In: Progress in Clinical and Biological Research (Eds. K. Yoshinaga and T. Mori), Alan R.
Liss, Inc., New York, pp. 401-412, 1989.
 

Dey, S.K. and D.C. Johnson.
Embryonic signals in pregnancy.
Annals N.Y.Acad. Sci., 476:49-62, 1986.
 

Kantor, B. and S.K. Dey.
Catechol oestradiol induced implantation in the delayed implanting rat.
Acta Endocrinol. 109:412-418, 1985.

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