The Division of Reproductive and Developmental Biology Department of Pediatrics at Vanderbilt University Medical Center VU Help Search Vanderbilt Medical Center Jeff Reese, MD Sanjoy K. Das, Ph.D Bibhash C. Paria, Ph.D S. K. Dey, Ph.D
The Division of Reproductive and Developmental Biology



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PROSTAGLANDIN SIGNALING
Prostaglandins are lipid-derived mediators of inflammation and tumorigenesis that function as cellular messengers. Prostaglandins are involved in all aspects of reproduction. The following papers describe our recent studies on the role of prostaglandins in reproduction.

Song H, Lim H, Paria BC, Matsumoto H, Swift LL, Morrow J, Bonventre JV, Dey SK.
Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development.
Development. 2002 Jun;129(12):2879-89.


Matsumoto H, Ma WG, Daikoku T, Zhao X, Paria BC, Das SK, Trzaskos JM, Dey SK.
Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice.
J Biol Chem. 2002 Aug 9;277(32):29260-7.


Reese J, Zhao X, Ma WG, Brown N, Maziasz TJ, Dey SK.
Comparative analysis of pharmacologic and/or genetic disruption of cyclooxygenase-1 and cyclooxygenase-2 function in female reproduction in mice.
Endocrinology. 2001 Jul;142(7):3198-206.


Matsumoto H, Ma W, Smalley W, Trzaskos J, Breyer RM, Dey SK.
Diversification of cyclooxygenase-2-derived prostaglandins in ovulation and implantation.
Biol Reprod. 2001 May;64(5):1557-65.


Lim H, Dey SK.
PPAR delta functions as a prostacyclin receptor in blastocyst implantation.
Trends Endocrinol Metab. 2000 May-Jun;11(4):137-42. Review.


Scherle PA, Ma W, Lim H, Dey SK, Trzaskos JM.
Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy.
J Biol Chem. 2000 Nov 24;275(47):37086-92.


Reese J, Paria BC, Brown N, Zhao X, Morrow JD, Dey SK.
Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse.
Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9759-64.


Song H, Lim H, Das SK, Paria BC, Dey SK.
Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient mice.
Mol Endocrinol. 2000 Aug;14(8):1147-61.


Reese J, Brown N, Paria BC, Morrow J, Dey SK.
COX-2 compensation in the uterus of COX-1 deficient mice during the pre-implantation period.
Mol Cell Endocrinol. 1999 Apr 25;150(1-2):23-31.


Lim H, Gupta RA, Ma WG, Paria BC, Moller DE, Morrow JD, DuBois RN, Trzaskos JM, Dey SK.
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta.
Genes Dev. 1999 Jun 15;13(12):1561-74.


Kim JJ, Wang J, Bambra C, Das SK, Dey SK, Fazleabas AT.
Expression of cyclooxygenase-1 and -2 in the baboon endometrium during the menstrual cycle and pregnancy.
Endocrinology. 1999 Jun;140(6):2672-8.


Das SK, Wang J, Dey SK, Mead RA.
Spatiotemporal expression of cyclooxygenase 1 and cyclooxygenase 2 during delayed implantation and the periimplantation period in the Western spotted skunk.
Biol Reprod. 1999 Apr;60(4):893-9.


Reese J, Brown N, Paria BC, Morrow J and Dey SK.
COX-2 compensation in the uterus of COX-1 deficient mice during the preimplantation period.
Mol Cell Endocrinol 150 (1-2):23-31, 1999.
 

Kim JJ, Wang, J, Bambra C, Das SK, Dey SK and Fazleabas AT.
Expression of cyclooxygenase-1 and -2 in the baboon endometrium during the menstrual cycle and pregnancy.
Endocrinology 140:2672-2678, 1999.
 

Das SK, Wang J, Dey SK and Mead RA.
Spatiotemporal expression of cyclooxygenase-1 and cyclooxygenase-2 during delayed implantation and periimplantation period in Western spotted skunk.
Biol Reprod 60:893-899, 1999.
 

Lim H, Paria BC, Das SK, Dinchuk JE, Langenbach R, Trzaskos JM and Dey SK.
Multiple female reproductive failures in cyclooxygenase 2-deficient mice.
Cell 91:197-208, 1997.
 

Lim H and Dey SK.
Prostaglandin E2 receptor subtype gene in the mouse uterus is associated with differentiation of the luminal epithelium for implantation.
Endocrinology 138:4599-4606, 1997.
 

Yang Z-M, Das SK, Wang J, Sugimoto Y, Ichikawa A and Dey SK.
Potential sites of prostaglandin actions in the periimplantation mouse uterus: Differential expression and regulation of prostaglandins receptor genes.
Biol Reprod 56:368-379, 1997.
 

Chakraborty I, Das SK, Wang J and Dey SK.
Developmental expression of the cyclooxygenase-1 and cyclooxygenase-2 genes in the periimplantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids.
J Mol Endo 16:107-122, 1996.
 

Paria, B.C., Das, S.K., Gupta, A., and Dey, S.K.
Reversal of Indomethacin Induced Inhibition of Implantation by epidermal growth factor.
Prostaglandins 42: 191-199, 1991.
 

Tawfik, O.W. and S.K. Dey.
Further evidence for role of leukotrienes as mediators of decidualization in the rat.
Prostaglandins 35:379-386, 1988
 

Tawfik, O.W., C. Sagrillo, D.C. Johnson, and S.K. Dey.
Decidualization in the rat: role of leukotrienes and prostaglandins.
Prostaglandins, Leukotrienes and Medicine 29:221-227, 1987.
 

Tawfik, O.W., Y.M. Huet, P.V. Malathy, D.C. Johnson, and S.K. Dey.
Release of prostaglandins and leukotrienes from the rat uterus is an early estrogenic response.
Prostaglandins 34:805-815, 1987.
 

Parr, M.B., E.L. Parr, K. Munaretto, M.R. Clark, and S.K. Dey.
Immunohistochemical localization of prostaglandin synthase in the rat uterus and embryo during the peri-implantation period.
Biol. Reprod. 38:333-343, 1987.
 

Malathy, P.V., H.C. Cheng and S.K. Dey.
Production of leukotrienes and prostaglandins in the rat uterus during peri-implantation period.
Prostaglandins 32:605-614, 1986.
 

Pakrasi, P.L, R. Becka and S.K. Dey.
Cyclooxygenase and lipoxygenase pathways in the preimplantation rabbit uterus and blastocyst.
Prostaglandins 29:481, 1985.
 

Pakrasi, P.L and S.K. Dey.
Evidence for an inverse relationship between cyclooxygenase and lipoxygenase pathways in the pregnant rabbit endometrium.
Prostaglandins, Leukotrienes and Medicine. 18:347, 1985.
 

Pakrasi, P.L., S.K. Dey and D.C. Johnson.
Studies on the temporal pattern of prostaglandin synthesis in the uterus of the delayed implanting rat with or without implantation inducing stimuli.
Prostaglandins, Leukotriens and Medicine 14:365, 1984.
 

Pakrasi, P.L and S.K. Dey.
Prostaglandins in the uterus: Modulation by steroid hormones.
Prostaglandins 26:991, 1983.
 

Pakrasi, P.L and S.K. Dey.
Catechol estrogens stimulate synthesis of prostaglandins in the preimplantation rabbit blastocyst and endometrium.
Biol. Reprod. 29:347, 1983.
 

Terranova, P.F. and S.K. Dey.
Indomethacin delays zona-shedding and Implantation in the ovariectomized progesterone-treated hamster.
Prostaglandins 24:165, 1982.

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