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Journal Cover gallery: click on cover to enlarge
| 1. | Shaken, not stirred: Collapsing a peptoid monolayer to produce free-floating, stable nanosheets. |
LBNL press release: |
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| 2. | Protein Side-Chain Translocation Mutagenesis via Incoproration of Peptoid Residues. |
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| 3. | Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets. |
Video preview in "This month in JoVE" (1 min). | ||
| 4. | Protein Mimicry with Bioinspired Peptoid Polymers. |
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| 5. | Peptoid Origins. |
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| 6. | A Universal Method for Detection of Amyloidogenic Misfolded Proteins. Yam, A.Y.; Wang, X.; Gao, C.; Connolly, M.D.; Zuckermann, R.N.; Bleua, T.; Halla, J.; Fedynyshyn, J.; Allauzen, S.; Peretz, D.; Salisbury, C.M., Biochem., 50, 4322-4329 (2011). Supporting Info. |
LBNL press release: |
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| 7. | Peptoids - Synthesis, Characterization, and Nanostructures. |
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| 8. | Folding of a Single-Chain, Information-Rich Polypeptoid Sequence into a Highly-Ordered Nanosheet. |
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9. |
BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications. Gelain, F.; Silva, D.; Villa, O.; Taraballi, F.; Natalello, A.; Caprini, A.; Nam, K.T.; Zuckermann, R.N.; Doglia, S.M.; Vescovi, A., ACS Nano, 5, 1845-1859 (2011). |
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| 10. | Engineered Biomimetic Polymers as Tunable Agents for Controlling CaCO3 Mineralization. |
Top story in EFRC Newsletter: |
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| 11. | Stabilization of nanoparticles under biological assembly conditions using peptoids. |
| 12. | AB40 Oligomers Identified as a Potential Biomarker for the Diagnosis of Alzheimer’s Disease. |
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| 13. | Hierarchical Self-Assembly of a Biomimetic Diblock Copolypeptoid into Homochiral Super Helices. |
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| 14. | Control of Crystallization and Melting Behavior in Sequence Specific Polypeptoids. |
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| 15. | Free-floating ultra-thin two-dimensional crystals from sequence-specific peptoid polymers. |
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LBNL press release: |
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| 16. | Gold Nanoparticle Self-Similar Chain Structure Organized by DNA Origami. Ding, B.; Deng, Z.; Yan, H.; Cabrini, S.; Zuckermann, R.N.; Bokor, J., J. Am. Chem. Soc., 132, 3248-3249 (2010). Supporting Info. |
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| 17. | Templated display of biomolecules and inorganic nanoparticles by metal ion-induced peptide nanofibers. |
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| 18. | Novel Peptoid Building Blocks: Synthesis of Functionalized Aromatic Helix-Inducing Submonomers. |
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| 19. | Rapid Multistep Synthesis of a Bioactive Peptidomimetic Oligomer for the Undergraduate Laboratory. |
| 20. | High-Throughput Sequencing of Peptoids and Peptide−Peptoid Hybrids by Partial Edman Degradation and Mass Spectrometry. |
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| 21. | DNA directed assembly of nanoparticle linear structure for nanophotonics. Ding, B.; Cabrini, S.; Zuckermann, R.N.; Bokor, J., J. Vac. Sci. Technol. B, 27, 184-187 (2009). |
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| 22. | Peptoids as Potential Therapeutics. |
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| 23. | Close mimicry of lung surfactant protein B by "clicked" dimers of helical, cationic peptoids. Dohm, M.T.; Seurynck-Servoss, S.L.; Seo, J.; Zuckermann, R.N.; Barron, A.E., Peptide Sci. 92, 538-553 (2009). Supporting Info. |
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| 24. | Biomimetic Nanostructures: Creating a High-Affinity Zinc-Binding Site in a Folded Nonbiological Polymer. |
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LBNL press release: "Nano-sized Jaws Perform Like Proteins" |
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| 25. | Intranasal administration delivers peptoids to the rat central nervous system. Ross, T.M.; Zuckermann, R.N.; Reinhard, C.; Frey, W.H., Neuroscience Letters, 439, 30-33, (2008). |
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| 26. | In vitro self-assembly of tailorable nanotubes from a simple protein building block. Ballister, E.R.; Lai, A.H.; Zuckermann, R.N.; Cheng, Y.; Mougous, J.D., Proc. Natl. Acad. Sci. U. S. A. 105, 3733-3738 (2008). |
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| 27. | Peptoids that mimic the structure, function and mechanism of helical antimicrobial peptides. Chongsiriwatana, N.P.; Patch, J.A.; Czyzewski, A.M.; Dohm, M.T.; Ivankin, A.; Gidalevitz, D.; Zuckermann, R.N.; Barron, A.E., Proc. Natl. Acad. Sci. U. S. A. 105, 2794-2799 (2008). |
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28. |
Bio-inspired Polymers for Nanoscience Research. Lee, B.-C.; Connolly, M. D.; Zuckermann, R. N., Proc. NSTI Nanotech 2, 28-31 (2007). |
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29. |
A peptidomimetic siRNA transfection reagent for highly effective gene silencing. |
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| 30. | A Threaded Loop Conformation Adopted by a Family of Peptoid Nonamers. Huang, K.; Wu, C. W.; Sanborn, T. J.; Patch, J. A.; Kirshenbaum, K.; Zuckermann, R. N.; Barron, A. E.; Radhakrishnan, I., J. Am. Chem. Soc. 128, 1733-1738 (2006). |
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| 31. | A Cleavable Hydrophilic Linker for One-Bead-One-Compound Sequencing of Oligomer Libraries by Tandem Mass Spectrometry. Paulick, M. G.; Hart, K. M.; Brinner, K. M.; Tjandra, M.; Charych, D. H.; Zuckermann, R. N., J. Comb. Chem. 8, 417-426 (2006). |
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32. |
Synthesis of Long Non-natural Sequence-Specific Heteropolymers. |
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33. |
Folding a Nonbiological Polymer into a Compact Multihelical Structure. |
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34. |
Incorporation of Chemoselective Functionalities into Peptoids via Solid-Phase Submonomer Synthesis. |
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35. |
Versatile Oligo(N-Substituted) Glycines: The Many Roles of Peptoids in Drug Discovery |
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36. |
Incorporation of Unprotected Heterocyclic Side Chains into Peptoid Oligomers via Solid-Phase Submonomer Synthesis. |
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37. |
Structure/Function Analysis of Peptoid/Lipitoid: DNA Complexes. |
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38. |
Structural and Spectroscopic Studies of Peptoid Oligomers with alpha-Chiral Aliphatic Side Chains. |
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39. |
Toward the Synthesis of Artificial Proteins: The Discovery of an Amphiphilic Helical Peptoid Assembly. |
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40. |
Extreme stability of helices formed by water-soluble poly-N-substituted glycines (polypeptoids) with alpha-chiral side chains. |
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41. |
Influence of Monomer Structural Elements in Hydrophilic Peptoids |
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42. |
The Application of Combinatorial Chemistry in Agrochemical Discovery |
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43. |
Peptoid Oligomers with alpha-Chiral Side Chains: Sequence Requirements for the Formation of Stable Peptoid Helices. |
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44. |
Peptoid Oligomers with alpha-Chiral, Aromatic Sidechains: Effects of Chain Length on Secondary Structure. |
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45. |
Improving SH3 Domain Ligand Selectivity Using a Non-natural Scaffold. |
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46. |
Bioinspired Polymeric Materials: In-between Proteins and Plastics. |
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47. |
Designing Polymers that Mimic Biomolecules. |
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48. |
New Submonomers for Poly N-Substituted Glycines (Peptoids). |
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49. |
Parallel Personal Comments on "Classical" Papers in Combinatorial Chemistry. |
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50. |
NMR Determination of the Major Solution Conformation of a Peptoid Pentamer with Chiral Side Chains. |
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51. |
Lipitoids - novel cationic lipids for cellular delivery of plasmid DNA in vitro. |
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52. |
Sequence-Specific Polypeptoids: A Diverse Family of Heteropolymers with Stable Secondary Structure. |
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53. |
A Combinatorial Approach to the Discovery of Efficient Cationic Peptoid Reagents for Gene Delivery. |
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54. |
Exploiting the Basis of Proline Recognition by SH3 and WW Domains: Design of N-Substituted Inhibitors. |
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55. |
Chiral N-Substituted Glycines Can Form Stable Helical Conformations. |
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| 56. | NMR Structural Characterization of Oligo-N-substituted Glycine Lead Compounds from a Combinatorial Library. Bradley, E.K., Kerr, J.M., Richter, L.S., Figliozzi, G.M., Goff, D.A., Zuckermann, R.N., Spellmeyer, D.C. & Blaney, J.M. Mol. Diversity 3, 1-15 (1997). |
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57. |
Developing a General Strategy for the Solid Supported Synthesis of Heterocycles: Applications to the Generation of Molecular Diversity and Drug Discovery. |
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58. |
Submonomer Approaches for the Generation of Molecular Diversity: Non-natural Oligomer and Organic Template Libraries |
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59. |
Accelerating Drug Discovery by High-Throughput Combinatorial Synthesis. |
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60. |
Synthesis of N-(substituted)glycine Peptoid Libraries. |
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61. |
Pharmacologic Characterization of CHIR 2279, an N-Substituted Glycine Peptoid with High-Affinity Binding for alpha1-Adrenoreceptors. |
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62. |
The Synthesis of 2-Oxopiperazines by Intramolecular Michael Addition on Solid Support. |
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63. |
Automated Synthesis of Non-Natural Oligomer Libraries: The Peptoid Concept |
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64. |
Solid-Phase Synthesis of Defined 1,4-Benzodiazepine-2,5-dione Mixtures. |
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65. |
Solid-Phase Synthesis of Highly Substituted Peptoid 1(2H)-Isoquinolinones. |
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66. |
Comparison of the Proteolytic Susceptibilities of Homologous L-Amino Acid, D-Amino Acid, and N-Substituted Glycine Peptide and Peptoid Oligomers. |
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67. |
Synthesis of Peptide Nucleic Acids (PNA) by Submonomer Solid Phase Synthesis. |
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68. |
Recent Advances in the Generation of Chemical Diversity Libraries. |
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69. |
Free C-terminal Resin-bound Peptides: Reversal of Peptide Orientation via a Cyclization/Cleavage Protocol. |
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70. |
Proteolytic Studies of Homologous peptide and N-Substituted Glycine Peptoid Oligomers. |
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71. |
Using Peptoid Libraries [Poly N-Substituted Glycines] for Drug Discovery. |
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72. |
Automated Tools for the Production of Non-Natural Molecular Diversity |
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73. |
Synthesis of (N-Substituted)Glycine Polymers of Defined Length and Sequence. |
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74. |
Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein Coupled Receptors from a Diverse (N-Substituted)Glycine Peptoid Library. |
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75. |
Molecular Mechanics Calculations of the Structures of Polyamide Nucleic Acid DNA Duplexes and Triple Helical Hybrids. |
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76. |
Identification of Antibody Mimotopes Containing Non-natural Amino Acids by Recombinant and Synthetic Peptide Library Affinity Selection Methods. |
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77. |
Encoded Combinatorial Peptide Libraries Containing Non-natural Amino Acids. |
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78. |
The Chemical Synthesis of Peptidomimetic Libraries. |
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79. |
Automated Tools for Drug Discovery: Robotic Equimolar Peptide Mixture Synthesis. |
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80. |
Simplified Methods for Construction, Assessment and Rapid Screening of Peptide Libraries in Bacteriophage. |
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81. |
Peptoids: A Modular Approach to Drug Discovery. |
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82. |
Automated Peptide-Resin Deprotection/Cleavage by a Robotic Workstation. |
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83. |
Efficient Method for the Preparation of Peptoids [Oligo(N-substituted glycines)] by Submonomer Solid Phase Synthesis. |
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84. |
Identification of Highest-Affinity Ligands by Affinity Selection from Equimolar Peptide Mixtures Generated by Robotic Synthesis. |
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85. |
Control of the Zymate Robot with an External Computer: Construction of a Multiple Peptide Synthesizer. |
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86. |
Construction and Application of a Fully Automated Equimolar Peptide Mixture Synthesizer. |
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87. |
Hybrid Enzymes and the Sequence-Specific Cleavage of Nucleic Acids |
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88. |
Site-Selective Cleavage of Structured RNA by a Staphylococcal Nuclease-DNA Hybrid. |
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89. |
Site-Selective Cleavage of RNA by a Hybrid Enzyme. |
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90. |
A Hybrid Sequence-Selective Ribonuclease S. |
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91. |
Efficient Methods for Attachment of Thiol-Specific Probes to the 3'-end of Synthetic Oligodeoxyribonucleotides. |
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92. |
A Synthesis of 2-Fluoro-2-alkenes. |
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93. |
Dynamic Cis-Trans Isomerization of Retinal in Dark-Adapted Bacteriorhodopsin. |